Identification of PIK3CA mutations in androgen receptor (AR) + triple-negative breast cancer (TNBC) cell lines and tumors. (A) Table displays the frequency of PIK3CA mutations (H1047R) in 25 TNBC AR + and 25 AR- TNBC human tumors. (B) Panel displays the TNBC molecular subtypes of The Cancer Genome Atlas (TCGA) breast cancer tumors with corresponding heatmaps showing the relative levels of AR RNA (RNA-seq) and AR protein (reverse-phase protein array (RPPA)). Those cases lacking protein or RNA evaluation are colored in black. The bottom row is a color bar indicating PIK3CA mutations (red) or wild-type (black) within the TCGA TNBC cases.