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Table 3 Least-square mean change in mammographic percentage density by genotype and treatment arm, adjusted

From: Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study

Genotype Placebo   ET   EPT   
  Mean (N) SEM P* Mean (N) SEM P Mean (N) SEM P P
COMT Val158Met           
Val/Val - 0.1 (30) 1.4 Ref. 3.7 (30) 1.4 Ref. 8.0 (12) 2.3 Ref.  
Val/Met 0.5 (45) 1.2 0.74 4.3 (48) 1.1 0.72 6.2 (19) 1.9 0.54  
Met/Met - 0.6 (19) 1.8 0.82 6.0 (25) 1.6 0.27 9.8 (3) 4.5 0.72 0.77
CYP1B1 Val432Leu           
Val/Val - 0.7 (15) 1.9 Ref. 4.7 (23) 1.6 Ref. 6.9 (7) 2.9 Ref.  
Leu/Val - 0.01 (42) 1.2 0.75 5.8 (44) 1.2 0.57 1.3 (13) 2.1 0.11  
Leu/Leu 0.9 (36) 1.2 0.47 3.6 (37) 1.2 0.61 14.5 (13) 2.1 0.03 0.0004
UGT1A1           
<7/<7 TA repeats 0.3 (37) 1.3 Ref. 5.7 (50) 1.1 Ref. 7.1 (18) 1.9 Ref.  
<7/≥ 7 TA repeats - 0.5 (43) 1.2 0.60 3.3 (39) 1.3 0.15 8.7 (12) 2.3 0.57  
≥ 7/≥ 7 TA repeats 0.6 (14) 2.1 0.92 4.4 (14) 2.1 0.58 5.4(3) 4.6 0.74 0.77
AKR1C4 L311V           
Leu/Leu - 0.3 (72) 0.9 Ref. 4.3 (79) 0.8 Ref. 4.0 (25) 1.6 Ref.  
Leu/Val 1.5 (21) 1.6 0.30 5.5 (25) 1.5 0.47 16.7 (7) 2.8 0.0001  
Val/Val 0.6 (1)   0.90 (0)    29.3 (1)   0.0007 0.001
  1. Figures are adjusted for race, age at baseline, years since menopause, body mass index (BMI) at baseline, change in BMI on trial, mammographic percentage density at baseline, past use of hormone therapy and study group.
  2. *Analysis of covariance P for comparison of means; analysis of covariance P for ET/EPT × genotype interaction. AKR1C4, aldo-keto reductase 1C4; COMT, catechol-O-methyltransferase; CYP1B1, cytochrome P450 1B1; EPT, estrogen and progestin therapy; ET, estrogen therapy; UGT1A1, UDP-glucuronosyltransferase 1A1.
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