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Table 3 Three trials reporting negative experiences with partial breast irradiation

From: Accelerated partial breast irradiation: the case for current use

    

Local recurrence

Trial

Technique

Selection criteria

Quality assurance

Whole breast

Partial breast

Christies Hospital [25]

Electron beam quadrant

No margin, stage, or histologic criteria

No image guidance or verification of coverage

8%

34%

Guys Hospital [26]

Cs137 MDR, 45 Gy

Positive margins, nodes, EIC

Dose, targeting, and volume issues

NA

20%

London Regional [28]

Ir192 HDR

Positive nodes, EIC

Small volume implants

NA

16%

  1. EIC, extensive intraductal component; HDR, high-dose rate; MDR, medium-dose rate.