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Table 2 Genotype frequencies and genotype-specific risks in 2192 women with breast cancer and 2257 controls

From: Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case–control study

SNP Series Rare-allele frequency Common homozygote No. (%) Heterozygote No. (%) Rare homozygote No. (%) Number genotyped P (2df)
SNP 1 Cases 0.13 1618 (77) 447 (21) 42 (2) 2107  
  Controls 0.13 1645 (75) 511 (23) 33 (2) 2189 0.13
  OR (95% CI)   1 (ref) 0.89 (0.77–1.03) 1.29 (0.82–2.05)   
SNP 2 Cases 0.25 1151 (57) 734 (36) 140 (7) 2025  
  Controls 0.26 1219 (55) 839 (38) 147 (7) 2205 0.48
  OR (95% CI)   1 (ref) 0.93 (0.82–1.05) 1.01 (0.79–1.29)   
SNP 3 Cases 0.32 962 (47) 855 (42) 219 (11) 2036  
  Controls 0.32 1022 (46) 956 (43) 230 (11) 2208 0.69
  OR (95% CI)   1 (ref) 0.95 (0.84–1.08) 1.01 (0.82–1.24)   
SNP 4 Cases 0.25 1128 (57) 748 (37) 113 (6) 1989  
  Controls 0.25 1230 (57) 791 (37) 134 (6) 2155 0.69
  OR (95% CI)   1 (ref) 1.03 (0.91–1.17) 0.92 (0.71–1.20)   
SNP 5 Cases 0.33 911 (45) 870 (43) 233 (12) 2014  
  Controls 0.33 960 (44) 983 (45) 238 (11) 2181 0.45
  OR (95% CI)   1 (ref) 0.93 (0.82–1.06) 1.03 (0.84–1.26)   
  1. OR, odds ratio; SNP, single-nucleotide polymorphism.