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Table 2 Relationship between APC7 expression and various clinicopathological parameters in invasive ductal carcinomas of the breast

From: Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

Characteristics All cases APC7 positive APC7 negative P a (significance)
All carcinomas 108 (100%) 68 (63.0%) 40 (37.0%)  
Tumor size     0.8180 (NSb)
Small (<5 cm) 81 (100%) 51 (63.0%) 30 (37.0%)  
Large (≥ 5 cm) 27 (100%) 17 (63.0%) 10 (37.0%)  
Metastasis     0.9703 (NS)
Negative 47 (100%) 29 (61.7%) 18 (38.3%)  
Positive 61 (100%) 39 (63.9%) 22 (36.1%)  
Clinical stage     0.2798 (NS)
I 19 (100%) 15 (78.9%) 4 (21.1%)  
II 65 (100%) 39 (60.0%) 26 (40.0%)  
III 24 (100%) 14 (58.3%) 10 (41.7%)  
ERc     0.1031 (NS)
Positive 51 (100%) 36 (70.6%) 15 (29.4%)  
Negative 51 (100%) 27 (52.9%) 24 (47.1%)  
Histologic grade     0.001
I 33 (100%) 28 (84.8%) 5 (15.2%)  
II 55 (100%) 33 (60.0%) 22 (40.0%)  
III 20 (100%) 7 (35.0%) 13 (65.0%)  
Nuclear grade     0.0090
1 6 (100%) 6 (100%) 0 (0%)  
2 87 (100%) 57 (65.5%) 30 (34.5%)  
3 15 (100%) 5 (33.3%) 10 (66.7%)  
Mitotic number (n/10 hpfd)     0.0016
<10 49 (100%) 37 (75.5%) 12 (24.5%)  
10–19 41 (100%) 26 (63.4%) 15 (36.6%)  
≥20 18 (100%) 5 (27.8%) 13 (72.2%)  
Ki-67 labeling indexe     0.0078
L (<25.5) 63 (100%) 58 (76.2%) 15 (23.8%)  
H (≥ 25.5) 41 (100%) 20 (48.8%) 21 (51.2%)  
DNA ploidyf     0.0095
Diploidy 17 (100%) 16 (94.1%) 1 (5.9%)  
Aneuploidy 77 (100%) 44 (57.1%) 33 (42.9%)  
  1. aχ2 test. bNot significant (P > 0.05). cEstrogen receptor (ER): because of an insufficient amount of some carcinoma tissues, we could not obtain meaningful ER staining data from six of the 108 breast carcinoma tissues. dhpf, high power field. eKi-67 (%): labeling index of Ki-67. The H and L groups were categorized in terms of being higher or lower than the mean index (25.5) in all cases. The mean indices of the L and H groups were 22.17 and 31.79, respectively. Because of an insufficient amount of some carcinoma tissues, we could not obtain meaningful Ki-67 staining data from four of the 108 breast carcinoma tissues. fDNA ploidy: in some cases we did not perform flow cytometry because of insufficient tissues. In another case, we could not interpret DNA ploidy data because of a high coefficient of variance (over 8.0). We obtained meaningful data for 94 tissue samples.