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Table 2 Relationship between APC7 expression and various clinicopathological parameters in invasive ductal carcinomas of the breast

From: Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

Characteristics

All cases

APC7 positive

APC7 negative

P a (significance)

All carcinomas

108 (100%)

68 (63.0%)

40 (37.0%)

 

Tumor size

   

0.8180 (NSb)

Small (<5 cm)

81 (100%)

51 (63.0%)

30 (37.0%)

 

Large (≥ 5 cm)

27 (100%)

17 (63.0%)

10 (37.0%)

 

Metastasis

   

0.9703 (NS)

Negative

47 (100%)

29 (61.7%)

18 (38.3%)

 

Positive

61 (100%)

39 (63.9%)

22 (36.1%)

 

Clinical stage

   

0.2798 (NS)

I

19 (100%)

15 (78.9%)

4 (21.1%)

 

II

65 (100%)

39 (60.0%)

26 (40.0%)

 

III

24 (100%)

14 (58.3%)

10 (41.7%)

 

ERc

   

0.1031 (NS)

Positive

51 (100%)

36 (70.6%)

15 (29.4%)

 

Negative

51 (100%)

27 (52.9%)

24 (47.1%)

 

Histologic grade

   

0.001

I

33 (100%)

28 (84.8%)

5 (15.2%)

 

II

55 (100%)

33 (60.0%)

22 (40.0%)

 

III

20 (100%)

7 (35.0%)

13 (65.0%)

 

Nuclear grade

   

0.0090

1

6 (100%)

6 (100%)

0 (0%)

 

2

87 (100%)

57 (65.5%)

30 (34.5%)

 

3

15 (100%)

5 (33.3%)

10 (66.7%)

 

Mitotic number (n/10 hpfd)

   

0.0016

<10

49 (100%)

37 (75.5%)

12 (24.5%)

 

10–19

41 (100%)

26 (63.4%)

15 (36.6%)

 

≥20

18 (100%)

5 (27.8%)

13 (72.2%)

 

Ki-67 labeling indexe

   

0.0078

L (<25.5)

63 (100%)

58 (76.2%)

15 (23.8%)

 

H (≥ 25.5)

41 (100%)

20 (48.8%)

21 (51.2%)

 

DNA ploidyf

   

0.0095

Diploidy

17 (100%)

16 (94.1%)

1 (5.9%)

 

Aneuploidy

77 (100%)

44 (57.1%)

33 (42.9%)

 
  1. aχ2 test. bNot significant (P > 0.05). cEstrogen receptor (ER): because of an insufficient amount of some carcinoma tissues, we could not obtain meaningful ER staining data from six of the 108 breast carcinoma tissues. dhpf, high power field. eKi-67 (%): labeling index of Ki-67. The H and L groups were categorized in terms of being higher or lower than the mean index (25.5) in all cases. The mean indices of the L and H groups were 22.17 and 31.79, respectively. Because of an insufficient amount of some carcinoma tissues, we could not obtain meaningful Ki-67 staining data from four of the 108 breast carcinoma tissues. fDNA ploidy: in some cases we did not perform flow cytometry because of insufficient tissues. In another case, we could not interpret DNA ploidy data because of a high coefficient of variance (over 8.0). We obtained meaningful data for 94 tissue samples.