Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

Table 1 Expression of APC7 in various human tissues

Expression of APC7^a	Tissue type
	Normal tissue	Tumor tissue
Negative	Adipocytes, brain, hepatocytes, skeletal muscle cells, spinal cord	Lipoma, pleomorphic adenoma of salivary gland, low grade urothelial carcinoma, chondrosarcoma, adenoid cystic carcinoma, renal cell carcinoma, high grade ductal carcinoma of breast
Positive	Basal cells of epidermis, bronchial epithelium, ductal cells of breast, ductal cells of pancreas, ductal cells of salivary glands, endometrial glands, kidney epithelium, gastric mucosa, prostate glands and ducts, urothelial epithelium, fibroblasts, germinal center cells	Adenocarcinoma of colon, adenocarcinoma of endometrium, adenocarcinoma of pancreas, adenocarcinoma of prostate, adenocarcinoma of stomach, ductal carcinoma of pancreas, hepatocellular carcinoma, high grade urothelial carcinoma, papillary serous carcinoma of ovary, squamous cell carcinoma of esophagus, squamous carcinoma of cervix, leiomyosarcoma of uterus, malignant lymphoma, melanoma, seminoma of testis

^aImmunohistochemical data from tissue arrays (Tissue-Array Co., Seoul, Korea) stained with anti-anaphase-promoting complex (APC)7 antibodies. Tissue-array slides mounted with 50 normal or 50 tumor cores contained 17 normal or 22 tumor tissues, respectively, in triplicate or duplicate. Negative APC7 expression is represented by staining intensities of 0 or 1+, whereas positive expression is represented by staining intensities of 2+ or 3+, as designated in Fig. 2A. Average staining intensities of several cores were used to determine tissue expression.

ISSN: 1465-542X