| |
SULT1A1*1/*1 genotype
|
SULT1A1*2 allele carriera
|
Total
|
|---|
| |
Cases
|
Controls
|
ORb (95% CI)
|
Cases
|
Controls
|
ORb (95% CI)
|
Cases
|
Controls
|
ORb (95% CI)
|
|---|
|
NAT2 fast acetylatorc
|
|
Never active/passive
|
6
|
20
|
1 (ref)
|
8
|
18
|
1 (ref)
|
14
|
38
|
1 (ref)
|
|
Passive only
|
30
|
37
|
3.23 (1.05–9.92)
|
37
|
59
|
1.28 (0.50–3.31)
|
67
|
96
|
1.95 (0.97–3.91)
|
|
1–10 pack-years
|
22
|
53
|
1.26 (0.40–3.95)
|
30
|
74
|
0.76 (0.29–1.96)
|
52
|
127
|
0.98 (0.48–1.98)
|
|
11+ pack-years
|
23
|
38
|
2.21 (0.68–7.12)
|
20
|
50
|
0.75 (0.27–2.06)
|
43
|
88
|
1.22 (0.59–2.54)
|
|
NAT2 slow acetylator
|
|
Never active/passive
|
14
|
33
|
1 (ref)
|
11
|
39
|
1 (ref)
|
25
|
75
|
1 (ref)
|
|
Passive only
|
36
|
65
|
1.35 (0.62–2.91)
|
32
|
93
|
1.18 (0.53–2.66)
|
68
|
158
|
1.25 (0.72–2.16)
|
|
1–10 pack-years
|
37
|
76
|
1.24 (0.57–2.69)
|
46
|
117
|
1.34 (0.62–2.92)
|
83
|
193
|
1.24 (0.72–2.12)
|
|
11+ pack-years
|
30
|
46
|
1.83 (0.79–4.26)
|
36
|
60
|
2.07 (0.91–4.72)
|
66
|
106
|
1.85 (1.04–3.30)
|
-
aIncludes SULT1A1*1/*2 and SULT1A1*2/*2 genotypes. bOdds ratios (ORs) stratified for age by 5-year intervals; additional adjustment was made for first-degree family history (yes/no), breastfeeding (total number of months) and body mass index (weight [kg]/ height [m]2) as continuous variables, parity (0, 1–2, 3+ children), alcohol consumption (0, 1–18, ≥19 g/day), menopausal status (premenopausal, postmenopausal, unknown) and education (low, intermediate, high) as categorical variables. Data missing for one case and three controls. cNAT2 fast acetylators are carriers of at least one *4 (wild-type) allele.
