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Table 3 Odds ratios for breast cancer associated with smoking stratified by NAT2 acetylator status and SULT1A1 genotype

From: SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case–control study

 

SULT1A1*1/*1 genotype

SULT1A1*2 allele carriera

Total

 

Cases

Controls

ORb (95% CI)

Cases

Controls

ORb (95% CI)

Cases

Controls

ORb (95% CI)

NAT2 fast acetylatorc

Never active/passive

6

20

1 (ref)

8

18

1 (ref)

14

38

1 (ref)

Passive only

30

37

3.23 (1.05–9.92)

37

59

1.28 (0.50–3.31)

67

96

1.95 (0.97–3.91)

1–10 pack-years

22

53

1.26 (0.40–3.95)

30

74

0.76 (0.29–1.96)

52

127

0.98 (0.48–1.98)

11+ pack-years

23

38

2.21 (0.68–7.12)

20

50

0.75 (0.27–2.06)

43

88

1.22 (0.59–2.54)

NAT2 slow acetylator

Never active/passive

14

33

1 (ref)

11

39

1 (ref)

25

75

1 (ref)

Passive only

36

65

1.35 (0.62–2.91)

32

93

1.18 (0.53–2.66)

68

158

1.25 (0.72–2.16)

1–10 pack-years

37

76

1.24 (0.57–2.69)

46

117

1.34 (0.62–2.92)

83

193

1.24 (0.72–2.12)

11+ pack-years

30

46

1.83 (0.79–4.26)

36

60

2.07 (0.91–4.72)

66

106

1.85 (1.04–3.30)

  1. aIncludes SULT1A1*1/*2 and SULT1A1*2/*2 genotypes. bOdds ratios (ORs) stratified for age by 5-year intervals; additional adjustment was made for first-degree family history (yes/no), breastfeeding (total number of months) and body mass index (weight [kg]/ height [m]2) as continuous variables, parity (0, 1–2, 3+ children), alcohol consumption (0, 1–18, ≥19 g/day), menopausal status (premenopausal, postmenopausal, unknown) and education (low, intermediate, high) as categorical variables. Data missing for one case and three controls. cNAT2 fast acetylators are carriers of at least one *4 (wild-type) allele.