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Table 3 Odds ratios for breast cancer associated with smoking stratified by NAT2 acetylator status and SULT1A1 genotype

From: SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case–control study

  SULT1A1*1/*1 genotype SULT1A1*2 allele carriera Total
  Cases Controls ORb (95% CI) Cases Controls ORb (95% CI) Cases Controls ORb (95% CI)
NAT2 fast acetylatorc
Never active/passive 6 20 1 (ref) 8 18 1 (ref) 14 38 1 (ref)
Passive only 30 37 3.23 (1.05–9.92) 37 59 1.28 (0.50–3.31) 67 96 1.95 (0.97–3.91)
1–10 pack-years 22 53 1.26 (0.40–3.95) 30 74 0.76 (0.29–1.96) 52 127 0.98 (0.48–1.98)
11+ pack-years 23 38 2.21 (0.68–7.12) 20 50 0.75 (0.27–2.06) 43 88 1.22 (0.59–2.54)
NAT2 slow acetylator
Never active/passive 14 33 1 (ref) 11 39 1 (ref) 25 75 1 (ref)
Passive only 36 65 1.35 (0.62–2.91) 32 93 1.18 (0.53–2.66) 68 158 1.25 (0.72–2.16)
1–10 pack-years 37 76 1.24 (0.57–2.69) 46 117 1.34 (0.62–2.92) 83 193 1.24 (0.72–2.12)
11+ pack-years 30 46 1.83 (0.79–4.26) 36 60 2.07 (0.91–4.72) 66 106 1.85 (1.04–3.30)
  1. aIncludes SULT1A1*1/*2 and SULT1A1*2/*2 genotypes. bOdds ratios (ORs) stratified for age by 5-year intervals; additional adjustment was made for first-degree family history (yes/no), breastfeeding (total number of months) and body mass index (weight [kg]/ height [m]2) as continuous variables, parity (0, 1–2, 3+ children), alcohol consumption (0, 1–18, ≥19 g/day), menopausal status (premenopausal, postmenopausal, unknown) and education (low, intermediate, high) as categorical variables. Data missing for one case and three controls. cNAT2 fast acetylators are carriers of at least one *4 (wild-type) allele.