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Table 4 Relative risk of breast cancer by haplotype 2 status in the Nurses' Health Study

From: Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer

Diplotype

Case (frequency)

Control (frequency)a

OR (95% CI)

ORb (95% CI)

Other/other

832 (63)

1137 (66)

1.00 (reference)

1.00 (reference)

Hap2/other

429 (33)

531 (31)

1.11 (0.95–1.30)

1.09 (0.92–1.28)

Hap2/Hap2

53 (4.0)

47 (2.7)

1.62 (1.07–2.49)

1.62 (1.05–2.48)

  1. CI, confidence interval; Hap2, haplotype 2; OR, odds ratio.
  2. aSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
  3. bLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, family history of breast cancer, and history of benign breast disease. P value for trend = 0.05.