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Table 3 Relation of common BRCA1 haplotypes to risk of breast cancer in the Nurses' Health Study

From: Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer

Haplotypea

Caseb (frequency)

Controlb (frequency)

OR (95% CI)

ORc (95% CI)

C A G A

1195(46)

1637 (48)

1.0 (reference)

1.0 (reference)

C A G G

536 (20)

623 (18)

1.19 (1.03–1.37)

1.18 (1.02–1.37)

T A A A

233 (9)

281 (8)

1.11 (0.95–1.29)

1.13 (0.96–1.32)

T A G A

273 (10)

403 (12)

0.92 (0.77–1.10)

0.94 (0.78–1.13)

T G G A

384 (15)

475 (14)

1.15 (0.95–1.39)

1.13 (0.93–1.37)

  1. CI, confidence interval; OR, odds ratio.
  2. aOrder of SNPs: 33420 (rs799917, P871L), 38085 (rs8176166), 44059 (rs3737559), 64646 (rs8176267).
  3. bSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
  4. cLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, family history of breast cancer, and history of benign breast disease. ORs represent risk increase per copy of each haplotype carried. P for global test = 0.08.
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Breast Cancer Research

ISSN: 1465-542X

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