Skip to main content

Advertisement

Table 1 A selection of epidemiological studies on populations of women exposed to radiation from the atomic bombings or for medical purposes

From: Radiation and breast cancer: a review of current evidence

  No. of women No. of breast cancers    
Cohort Exposed Non-exposed Exposed Non- exposed Breast dose (Sv)b Exposure age (years)b ERR at 1 Svg
Atomic bombings        
   Life Span Study, Japan [43] 70,165 c 1059 - 0.28 27 1.74
Diagnostic radiation        
   Tuberculosis fluoroscopy, Canada [27]a 31,917 c 319 332 0.89 26 0.90
   Tuberculosis fluoroscopy, USA [28] 2573 2367 147 87 0.79 26 0.40
   Scoliosis, USA [29]a 4929 644 70 7 0.11 10 5.4
Radiotherapy for benign disorders        
   Enlarged thymus, USA [30] 1201 2469 22 12 0.69 <1 2.39
   Skin hemangioma, Sweden [31] 17,202 c 245 - 0.29 0.5 0.35
   Tinea Capitis, Israel [32] 5400 8100 25 27 0.02 7 -
   Benign breast disease, Sweden [33] 1216 1874 198 101 5.8 40 0.35
   Post-partum mastitis, USA [34] 601 1239 56 59 3.8 28 0.43
  No. of cancer survivors Observed Expected    RR/OE
Cancer survivors        
   Pediatric HL (age < 16) LESG, USA [35]d 480   29 0.7 f 11.7 55.5
   Childhood cancer, CCSS, USA [36]d 6304   60 3.7 f 7.8 24.7h
   Pediatric HL international [37] 2737   52 3.7 f 16 14.1
   HL, UK [38]d 2085   19 13.5 f - 2.5h
   Breast cancer, Denmark [39]e 56,540   529e - 2.5 51 1.04
   Breast cancer, USA [40]e 41,109   655e - 2.8 52 1.33
  1. CCSS, Childhood Cancer Survivor Study; ERR, excess relative risk; expected, expected number of cases; HL, Hodgkin lymphoma; LESG, Late Effects Study Group; observed, observed number of cases; OE, observed/expected ratio; RR, relative risk. aOutcome breast cancer mortality. bAverage. cIncluded in the exposed group. dIn the total cohorts 70–90% of patients were treated with radiotherapy. eNested case-control studies among patients with a first breast cancer and matched controls. fSpecific dose estimates were not reported in these studies, but HL patients can be exposed to doses of 40 Gy or more [41]. gSource: UNSCEAR 2000 report [26], which also has more detailed descriptions of the individual studies. hFor the subgroup of patients treated with chest radiotherapy.