TY - JOUR AU - Davies, Michael PA AU - O'Neill, Penny A. AU - Innes, Helen AU - Sibson, D. Ross PY - 2004 DA - 2004/11/23 TI - Hypersensitive K303R oestrogen receptor-α variant not found in invasive carcinomas JO - Breast Cancer Research SP - R113 VL - 7 IS - 1 AB - Genetic abnormalities or mutations in premalignant breast lesions may have a role in progression toward malignancy or influence the behaviour of subsequent disease. The A908G (Lys303→Arg) change in the gene encoding oestrogen receptor-α (ER-α) creates a hypersensitivity to oestradiol and would have significant consequences if present in breast carcinoma, especially those treated with endocrine therapy. We have therefore examined a panel of endocrine-treated invasive carcinomas for the presence of this mutation. SN - 1465-542X UR - https://doi.org/10.1186/bcr965 DO - 10.1186/bcr965 ID - Davies2004 ER -