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Figure 8 | Breast Cancer Research

Figure 8

From: Membrane estrogen receptor-α levels predict estrogen-induced ERK1/2 activation in MCF-7 cells

Figure 8

Dose-dependent 17β-estradiol (E2) activation of extracellular signal-regulated kinase (ERK)1/2 in membrane estrogen receptor (mER)-α-enriched (mERhigh) versus mER-α-depleted (mERlow) MCF-7 cells. Cells were incubated with different E2 concentrations at peak activation times: (a) 10 min in the case of mERhigh and (b) 6 min in the case of mERlow. The experiments were repeated three times, each with 16 replicates; values are expressed as mean ± standard error. The asterisks indicate significant differences from the vehicle controls (C).

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