Table 3 Logistic regression analysis of features of breast cancers among BRCA1- and BRCA2-associated cases in comparison with non-BRCA1/2 cases
Odds ratio (95% confidence interval, P) | ||
|---|---|---|
Feature | BRCA1 | BRCA2 |
First step: | ||
Age (continuous) | 0.94 (0.91–0.98, 0.0009) | 0.94 (0.91–0.97, 0.0001) |
Grade (continuous) | 3.78 (1.70–8.39, 0.0011) | 1.27 (0.71–2.26, 0.42) |
ER+ | 1.0 (referent) | 1.0 (referent) |
ER- | 0.91 (0.28–2.90, 0.88) | 0.85 (0.32–2.29, 0.75) |
PgR+ | 1.0 (referent) | 1.0 (referent) |
PgR- | 4.18 (1.26–13.87, 0.019) | 1.82 (0.75–4.38, 0.18) |
p53+ | 1.0 (referent) | 1.0 (referent) |
p53- | 1.96 (0.74–5.18, 0.18) | 1.61 (0.63–4.12, 0.34) |
Final step after stepwise regression: | ||
Age (continuous) | 0.94 (0.92–0.98, 0.0012) | 0.94 (0.92–0.97, 0.0001) |
Grade (continuous) | 3.25 (1.58–6.69, 0.0014) | |
PgR+ | 1.0 (referent) | |
PgR- | 3.45 (1.22–9.80, 0.02) | |