Skip to main content

Table 3 Logistic regression analysis of features of breast cancers among BRCA1- and BRCA2-associated cases in comparison with non-BRCA1/2 cases

From: Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families

  Odds ratio (95% confidence interval, P)
Feature BRCA1 BRCA2
First step:   
Age (continuous) 0.94 (0.91–0.98, 0.0009) 0.94 (0.91–0.97, 0.0001)
Grade (continuous) 3.78 (1.70–8.39, 0.0011) 1.27 (0.71–2.26, 0.42)
ER+ 1.0 (referent) 1.0 (referent)
ER- 0.91 (0.28–2.90, 0.88) 0.85 (0.32–2.29, 0.75)
PgR+ 1.0 (referent) 1.0 (referent)
PgR- 4.18 (1.26–13.87, 0.019) 1.82 (0.75–4.38, 0.18)
p53+ 1.0 (referent) 1.0 (referent)
p53- 1.96 (0.74–5.18, 0.18) 1.61 (0.63–4.12, 0.34)
Final step after stepwise regression:   
Age (continuous) 0.94 (0.92–0.98, 0.0012) 0.94 (0.92–0.97, 0.0001)
Grade (continuous) 3.25 (1.58–6.69, 0.0014)  
PgR+ 1.0 (referent)  
PgR- 3.45 (1.22–9.80, 0.02)  
  1. ER, oestrogen receptor; PgR, progesterone receptor.
\