Skip to main content

Table 1 Genotype distribution of the study population by gender, family relationship and affected status

From: Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study

 

Mothers

Daughters

   

Genotype

Affected

Unaffected

Affected

Unaffected

Fathers

Sons

Total

CYP17

       

   CC

2

10

47

41

6

11

117

   CT

8

32

147

108

30

22

347

   TT

2

19

107

61

8

18

215

   Unknown

64

140

0

0

233

0

437

   Total

76

201

301

210

277

51

1116

CYP19 (no. of TTTA repeats)

       

   7/7

1

15

88

55

7

21

187

   7/8

0

10

34

29

4

5

82

   7/9

0

0

1

0

1

0

2

   7/10

0

1

5

6

2

0

14

   7/11

9

19

106

71

14

19

238

   7/12

0

2

9

8

0

0

19

   7/13

0

0

0

0

1

0

1

   8/8

0

0

4

1

0

0

5

   8/10

0

1

3

2

0

0

6

   8/11

1

2

24

16

1

3

47

   8/12

0

0

1

2

0

0

3

   8/13

0

0

0

1

0

0

1

   9/11

0

0

0

1

0

0

1

   10/11

0

0

2

3

0

2

7

   11/11

0

5

19

16

1

1

42

   11/12

0

1

4

2

0

0

7

   11/13

1

0

2

1

1

0

5

   11/not 11a

1

3

0

0

5

0

9

   Unknown

63

143

0

0

241

0

447

   Total

76

202

302

214

278

51

1123

  1. aIndicates those whose genotype cannot be inferred for both alleles; the other allele could be 7, 8, or 12. Two of these nine observations, one an unaffected mother and the other the father in the same nuclear family, will be excluded when the allele with 10 or more repeats is selected as bad allele, because either them could be 11/12.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us