Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography

Table 4 Scintigraphic identification of breast carcinoma in situ with ^99mTc-(V)DMSA and ^99mTc-Sestamibi: classification of the studied population (n = 102) according to the histological diagnosis and the scintimammographic criterion set for ductal carcinoma in situ/lobular carcinoma in situ (DCIS/LCIS)

	Malignant lesions (n = 46)								Benign lesions (n = 56)
Histology	Carcinoma in situ, alone, or with invasive component (DCIS/LCIS ± IDC/ILC) (n = 20)				Invasive carcinoma (IDC/ILC) (n = 26)				Lesions with usual type, or atypical hyperplasia (UTH/ATH) (n = 14)				Lesions without hyperplasia (fibrosis, adenosis and ductal dilatation) (n = 42)
Radiotracer	^99mTc-(V)DMSA (n = 19)		^99mTc-Sestamibi (n = 13)		^99mTc-(V)DMSA (n = 25)		^99mTc-Sestamibi (n = 20)		^99mTc-(V)DMSA (n = 14)		^99mTc-Sestamibi (n = 14)		^99mTc-(V)DMSA (n = 14)		^99mTc-Sestamibi (n = 28)
Results (-) (n = 28)	(+) (n = 18)	(-) (n = 1)	(+) (n = 6)		(-) (n = 7)	(+) (n = 2)	(-) (n = 23)	(+) (n = 0)	(-) (n = 20)	(+) (n = 10)	(-) (n = 4)	(+) (n = 6)	(-) (n = 8)	(+) (n = 0)	(-) (n = 14)	(+) (n = 0)
Classification	TP	FN	TP	FN	FP	TN	FP	TN	FP	TN	FP	TN	FP	TN	FP	TN

^99mTc-(V)DMSA, technetium-99m pentavalent dimercaptosuccinic acid; ^99mTc-Sestamibi (^99mTc-MIBI), technetium-99m 2-methoxy isobutyl isonitrile; EIC, extensive intraductal component; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; UTH, usual type hyperplasia; ATH, atypical type hyperplasia; (+), positive scan; (-), negative scan; TP, true positive; FN, false negative; FP, false positive; TN, true negative.

ISSN: 1465-542X