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Table 4 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M4 genotypes in white women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa CYP1A1 M4 genotype All participants Premenopausal Postmenopausal
   Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b
<0.349 Non-M4 202/159 Referent 132/103 Referent 70/56 Referent
≥0.349 Non-M4 139/163 0.7 (0.5–1.0) 46/48 0.8 (0.5–1.2) 93/115 0.7 (0.4–1.1)
<0.349 Any M4 19/19 0.8 (0.4–1.6) 17/11 1.2 (0.5–2.7) 2/8 0.2 (0.0–0.9)
≥0.349 Any M4 14/17 0.7 (0.3–1.6) 5/5 0.8 (0.2–2.9) 9/12 0.7 (0.3–1.7)
ICR (95% CI)    0.2 (-0.6,1.0)   -0.1 (-1.6,1.3)   0.8 (0.1,1.5)
  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.