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Table 3 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M3 genotypes in African American women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa CYP1A1 M3 genotype All participants Premenopausal Postmenopausal
   Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b
<0.430 Non-M3 95/95 Referent 73/70 Referent 22/25 Referent
≥0.430 Non-M3 105/100 1.3 (0.8–2.0) 31/24 1.6 (0.8–3.2) 74/76 1.0 (0.5–2.0)
<0.430 Any M3 13/26 0.6 (0.3–1.2) 8/14 0.7 (0.3–1.7) 5/12 0.5 (0.2–1.6)
≥0.430 Any M3 29/21 1.6 (0.8–3.2) 7/6 1.5 (0.5–4.7) 22/15 1.5 (0.6–3.6)
ICR (95% CI)    0.8 (-0.3,1.9)   0.2 (-1.7,2.1)   1.0 (-0.2,2.1)
  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.