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Table 2 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M2 genotypes in white women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa CYP1A1 M2 genotype All participants Premenopausal Postmenopausal
   Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b
<0.349 Non-M2 210/158 Referent 141/98 Referent 69/60 Referent
≥0.349 Non-M2 138/166 0.7 (0.5–1.0) 45/51 0.6 (0.4–1.0) 93/115 0.8 (0.5–1.2)
<0.349 Any M2 11/20 0.4 (0.2–0.8) 8/16 0.3 (0.1–0.8) 3/4 0.7 (0.1–3.1)
≥0.349 Any M2 15/14 0.9 (0.4–1.9) 6/2 2.1 (0.4–10.6) 9/12 0.7 (0.3–1.9)
ICR (95% CI)    0.8 (0.1, 1.6)   2.1 (-1.3,5.5)   0.3 (-0.9,1.5)
  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.