Skip to main content

Table 1 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M1 genotypes in African American and white women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa

CYP1A1 M1 genotype

All participants

Premenopausal

Postmenopausal

  

Patients/controls

OR (95% CI)b

Patients/controls

OR (95% CI)b

Patients/controls

OR (95% CI)b

African Americans

       

<0.430

Non-M1

66/75

Referent

46/51

Referent

20/24

Referent

≥0.430

Non-M1

75/67

1.5 (0.9–2.5)

21/16

1.9 (0.9–4.2)

54/51

1.0 (0.5–2.3)

<0.430

Any M1

42/46

1.0 (0.6–1.7)

35/33

1.2 (0.6–2.2)

7/13

0.6 (0.2–1.8)

≥0.430

Any M1

59/54

1.4 (0.8–2.5)

17/14

1.7 (0.8–4.1)

42/40

1.0 (0.5–2.3)

ICR (95% CI)

  

0.0 (-0.9,0.9)

 

-0.3 (-2.2,1.6)

 

0.4 (-0.5,1.3)

Whites

       

<0.349

Non-M1

174/133

Referent

118/83

Referent

56/50

Referent

≥0.349

Non-M1

122 148

0.7 (0.5–1.0)

38/43

0.6 (0.4–1.1)

84/105

0.8 (0.5–1.3)

<0.349

Any M1

45/44

0.8 (0.5–1.2)

29/31

0.7 (0.4–1.2)

16/13

1.1 (0.5–2.5)

≥0.349

Any M1

29/32

0.8 (0.4–1.4)

11/10

0.7 (0.3–1.9)

18/22

0.8 (0.4–1.7)

ICR (95% CI)

  

0.4 (-0.2,0.9)

 

0.5 (-0.3,1.2)

 

0.0 (-1.1,1.0)

  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.