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Table 1 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M1 genotypes in African American and white women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa CYP1A1 M1 genotype All participants Premenopausal Postmenopausal
   Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b Patients/controls OR (95% CI)b
African Americans        
<0.430 Non-M1 66/75 Referent 46/51 Referent 20/24 Referent
≥0.430 Non-M1 75/67 1.5 (0.9–2.5) 21/16 1.9 (0.9–4.2) 54/51 1.0 (0.5–2.3)
<0.430 Any M1 42/46 1.0 (0.6–1.7) 35/33 1.2 (0.6–2.2) 7/13 0.6 (0.2–1.8)
≥0.430 Any M1 59/54 1.4 (0.8–2.5) 17/14 1.7 (0.8–4.1) 42/40 1.0 (0.5–2.3)
ICR (95% CI)    0.0 (-0.9,0.9)   -0.3 (-2.2,1.6)   0.4 (-0.5,1.3)
Whites        
<0.349 Non-M1 174/133 Referent 118/83 Referent 56/50 Referent
≥0.349 Non-M1 122 148 0.7 (0.5–1.0) 38/43 0.6 (0.4–1.1) 84/105 0.8 (0.5–1.3)
<0.349 Any M1 45/44 0.8 (0.5–1.2) 29/31 0.7 (0.4–1.2) 16/13 1.1 (0.5–2.5)
≥0.349 Any M1 29/32 0.8 (0.4–1.4) 11/10 0.7 (0.3–1.9) 18/22 0.8 (0.4–1.7)
ICR (95% CI)    0.4 (-0.2,0.9)   0.5 (-0.3,1.2)   0.0 (-1.1,1.0)
  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.