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Figure 6 | Breast Cancer Research

Figure 6

From: The p53-dependent apoptotic pathway of breast cancer cells (BC-M1) induced by the bis-type bioreductive compound aziridinylnaphthoquinone

Figure 6

Apoptosis induced by bis-aziridinylnapthoquinone (AZ-1) in MCF-7 cells. The MCF-7 cells were treated in 24-hour culture with (a) dimethylsulfoxide control, (b) 0.2 μM AZ-1, (c) 1.0 μM AZ-1, or (d) 2.0 μM AZ-1 before Hoechst staining and analysis of the DNA nuclei. Apoptotic cells showed blue, peripherally clumped or fragmented chromatin as indicated by the arrows.

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Breast Cancer Research

ISSN: 1465-542X

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