Figure 1

Bis-aziridinylnapthoquinone (AZ-1) inhibited the proliferation of three cell lines, skin fibroblasts (SF), BC-M1 and MCF-7. Cells were seeded for 18 hours before the addition of AZ-1 with various concentrations. The death effects of these three cell lines induced by various concentrations of AZ-1 were compared by the MTT assay. The MTT assay was used to determine the cell viability after an additional 24 hours of culture. Data are from quadruplet wells and are representative of three separate experiments.