Table 3 Frequency of CHEK2 variants in cases and controls according to age and family history features

Age (years)

< 30

10

16

0

0

0

0

   30–34

52

64

0

0

0

1

1.6

0.04–8.4

   35–39

156

140

1

0.6

0.02–3.5

1

0.7

0.02–3.9

1

0.6

0.02–3.5

0

   40–44

288

239

5

1.7

0.6–4.0

1

0.4

0.01–2.3

1

0.3

0.009–1.9

3

1.3

0.3–3.6

Family History of breast cancer^a

   None

280

294

2

0.7

0.09–2.6

1

0.3

0.009–1.9

1

0.4

0.009–2.0

3

1.0

0.2–3.0

   First-degree

94

36

4

4.3

1.2–10.5

0

1

1.1

0.03–5.8

0

   Second-degree only

120

115

0

1

0.9

0.02–4.7

0

1

0.9

0.02–4.7

Number of relatives with breast cancer^a

   None

280

294

2

0.7

0.09–2.6

1

0.3

0.009–1.9

1

0.4

0.009–2.0

3

1.0

0.2–3.0

   1

137

114

3

2.2

0.5–6.3

1

0.9

0.02–4.8

1

0.7

0.02–4.0

0

   2

51

29

1

2.0

0.05–10.4

0

0

1

3.4

0.09–17.8

   3+

26

8

0

0

0

0

Family history of ovarian cancer

   None

461

432

4

0.9

0.2–2.2

2

0.5

0.06–1.7

2

0.4

0.05–1.6

4

0.9

0.3–2.4

   1st or 2nd degree

45

27

2

4.4

0.5–15.1

0

0

0

Family history of breast and/or ovarian cancer^a

   No breast/no ovarian

258

278

2

0.8

0.09–2.8

1

0.4

0.009–2.0

1

0.4

0.01–2.1

3

1.1

0.2–3.1

   No breast/yes ovarian

22

16

0

0

0

0

   Yes breast/no ovarian

192

141

2

1.0

0.1–3.7

1

0.7

0.02–3.9

1

0.5

0.01–2.9

1

0.7

0.02–3.9

   Yes breast/yes ovarian

22

10

2

9.1

1.1–29.2

0

0

0