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Table 2 Prenatal Factors in Carolina Breast Cancer Study (CBCS) Analytic Datasets

From: Birthweight, parental age, birth order and breast cancer risk in African-American and white women: a population-based case–control study

  CBCS Analytic subgroups
  CBCS, full dataset CBCS, born 1948+ Maternal age dataset Birthweight dataset
  Cases Controls Cases Controls Cases Controls Cases Controls
  n (%) n (%) n (%) n (%) n (%) n (%) n (%) n (%)
Number 861 790 366 316 280 237 196 167
Age at selection/diagnosis (years)
   Mean ± SD 50.26 ± 11.93 51.83 ± 11.65 39.59 ± 5.29 40.65 ± 4.72 39.19 ± 5.43 40.68 ± 4.63 38.39 ± 5.29 39.95 ± 4.32
   Median 48 49 41 42 40 42 39 41
   Range 23–74 21–74 23–48 21–47 23–48 26–47 23–47 26–47
Birthplace
   NC born 583 (67.7) 550 (69.6) 235 (64.2) 207 (65.5) 220 (78.6) 198 (83.5) 196 (100.0) 167 (100.0)
   US born (outside NC) 261 (30.3) 218 (27.6) 121 (33.1) 98 (31.0) 60 (21.4) 39 (16.5) 0 (0.0) 0 (0.0)
   Non-US born 17 (2.0) 22 (2.8) 10 (2.7) 11 (3.5) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Prenatal factors
   Birthweight
Lower tertile NA   NA   NA   NA   NA   NA   73 (37.2) 57 (34.1)
Central tertile              70 (35.7) 54 (32.3)
Upper tertile              53 (27.0) 56 (33.5)
Mean ± SD              3210.7 ± 526.1 3262.5 ± 550.3
   Maternal age (years)
15–18 NA   NA   NA   NA   31 (11.1) 31 (13.1) 21 (10.7) 22 (13.3)
19–22          51 (18.2) 80 (33.8) 34 (17.3) 53 (31.9)
23–27          87 (31.1) 49 (20.7) 60 (30.6) 38 (22.9)
28–44          111 (39.6) 77 (32.5) 81 (41.3) 53 (31.9)
Mean ± SD          26.46 ± 6.48 25.18 ± 6.66 26.63 ± 6.46) 25.34 ± 6.82
   Paternal age (years)
15–22 NA   NA   NA   NA   39 (14.7) 35 (16.1) 26 (14.1) 21 (14.0)
23–27          73 (27.5) 69 (31.8) 47 (25.4) 50 (33.3)
28–34          87 (32.8) 67 (30.9) 66 (35.7) 49 (32.7)
35–56          66 (24.9) 46 (21.2) 46 (24.9) 30 (20.0)
Mean ± SD          29.97 ± 7.10 29.54 ± 7.46 30.24 ± 7.06) 29.71 ± 7.48
   Birth order (self-report)
First 297 (34.8) 268 (34.1) 117 (32.3) 108 (34.3) 88 (31.5) 80 (33.9) 56 (28.6) 53 (31.9)
Second-fourth 406 (47.5) 377 (48.0) 194 (53.6) 158 (50.2) 149 (53.4) 115 (48.7) 107 (54.6) 81 (48.8)
Fifth or higher 151 (17.7) 140 (17.8) 51 (14.1) 49 (15.6) 42 (15.1) 41 (17.4) 33 (16.8) 32 (19.3)
Mean ± SD 2.86 ± 2.30 2.87 ± 2.32 2.76 ± 2.12 2.74 ± 2.15 2.83 ± 2.22 2.84 ± 2.25 2.95 ± 2.22 3.01 ± 2.35
  1. NA, not available
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