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Table 2. Expected cases of breast and ovarian cancer in the IBCCS cohort as a function of the proportion of unaffected subjects, prophylactic surgery rates and length of follow-up. A cohort of 2000 women is assumed.

From: The International BRCA1 /2Carrier Cohort Study: Purpose, Rationale, and Study Design

Aff:Unaff %Mastectomy %Oophorectomy Expected Breast Cancers Expected Ovarian Cancers
    5 yrs 10 yrs 5 yrs 10 yrs
2:1 10 30 55 104 14 29
1:1 10 30 75 143 17 35
1:2 10 30 96 181 20 41
2:1 30 50 44 82 10 20
1:1 30 50 60 112 12 24
1:2 30 50 76 142 14 28
2:1 50 70 32 61 6 12
1:1 50 70 43 82 7 15
1:2 50 70 54 103 9 17