Table 2. Expected cases of breast and ovarian cancer in the IBCCS cohort as a function of the proportion of unaffected subjects, prophylactic surgery rates and length of follow-up. A cohort of 2000 women is assumed.
From: The International BRCA1 /2Carrier Cohort Study: Purpose, Rationale, and Study Design
Aff:Unaff | %Mastectomy | %Oophorectomy | Expected Breast Cancers | Expected Ovarian Cancers | ||
|---|---|---|---|---|---|---|
| Â | Â | Â | 5 yrs | 10 yrs | 5 yrs | 10 yrs |
2:1 | 10 | 30 | 55 | 104 | 14 | 29 |
1:1 | 10 | 30 | 75 | 143 | 17 | 35 |
1:2 | 10 | 30 | 96 | 181 | 20 | 41 |
2:1 | 30 | 50 | 44 | 82 | 10 | 20 |
1:1 | 30 | 50 | 60 | 112 | 12 | 24 |
1:2 | 30 | 50 | 76 | 142 | 14 | 28 |
2:1 | 50 | 70 | 32 | 61 | 6 | 12 |
1:1 | 50 | 70 | 43 | 82 | 7 | 15 |
1:2 | 50 | 70 | 54 | 103 | 9 | 17 |