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Table 4 Associations of breast cancer with the manganese superoxide dismutase polymorphism polymorphism, stratified by food and nutrient intake, in the Shanghai Breast Cancer Study

From: Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study

Stratified variable

Premenopausal women

Postmenopausal women

 

Val/Val

Val/Ala

Ala/Ala

Val/Val

Val/Ala

Ala/Ala

 

n a

ORb (95% CI)

n a

ORb

(95% CI)

n a

ORb

(95% CI)

n a

ORb (95% CI)

n a

ORb

(95% CI)

n a

ORb

(95% CI)

Total vegetables

            

   ≤ Median

273/290

1.0 (ref.)

89/88

1.1 (0.8–1.6)

9/4

2.4 (0.7–8.0)

145/164

1.0 (ref.)

49/44

1.3 (0.8–2.0)

4/6

0.7 (0.2–2.7)

   > Median

277/273

1.0 (ref.)

90/100

0.9 (0.6–1.2)

12/8

1.5 (0.6–3.7)

133/153

1.0 (ref.)

36/58

0.7 (0.5–1.2)

3/5

0.8 (0.2–3.3)

Total fruits

            

   ≤ Median

260/281

1.0 (ref.)

95/98

1.1 (0.8–1.5)

7/3

2.6 (0.7–10.0)

152/166

1.0 (ref.)

38/44

1.0 (0.6–1.6)

4/5

1.0 (0.3–3.8)

   > Median

290/282

1.0 (ref.)

84/90

0.9 (0.6–1.2)

14/9

1.5 (0.7–3.6)

126/151

1.0 (ref.)

47/58

1.0 (0.6–1.5)

3/6

0.6 (0.1–2.3)

Vitamin A

            

   ≤ Median

238/286

1.0 (ref.)

86/92

1.1 (0.8–1.6)

10/4

2.9 (0.9–9.2)

111/165

1.0 (ref.)

29/46

1.0 (0.6–1.6)

5/4

1.9 (0.5–7.3)

   > Median

312/277

1.0 (ref.)

93/96

0.9 (0.6–1.2)

11/8

1.3 (0.5–3.3)

167/152

1.0 (ref.)

55/56

0.9 (0.6–1.4)

2/7

0.3 (0.1–1.3)

Carotene

            

   ≤ Median

281/287

1.0 (ref.)

88/90

1.0 (0.7–1.5)

10/4

2.6 (0.8–8.4)

131/157

1.0 (ref.)

41/52

0.9 (0.6–1.5)

3/6

0.6 (0.1–2.4)

   > Median

269/276

1.0 (ref.)

91/98

0.9 (0.7–1.3)

11/8

1.4 (0.5–3.5)

147/160

1.0 (ref.)

44/50

1.0 (0.6–1.6)

4/5

0.9 (0.2–3.4)

Vitamin E

            

   ≤ Median

288/282

1.0 (ref.)

96/95

1.0 (0.7–1.4)

10/5

1.9 (0.7–5.7)

156/155

1.0 (ref.)

48/53

0.9 (0.6–1.5)

4/7

0.6 (0.2–2.1)

   > Median

262/281

1.0 (ref.)

83/93

1.0 (0.7–1.4)

11/7

1.8 (0.7–4.9)

122/162

1.0 (ref.)

37/49

1.1 (0.6–1.7)

3/4

1.0 (0.2–4.8)

Vitamin C

            

   ≤ Median

275/282

1.0 (ref.)

92/96

1.0 (0.7–1.4)

12/4

3.1 (1.0–9.8)

137/161

1.0 (ref.)

43/48

1.1 (0.7–1.7)

5/6

1.0 (0.3–3.3)

   > Median

275/281

1.0 (ref.)

87/92

1.0 (0.7–1.3)

9/8

1.1 (0.4–3.0)

141/156

1.0 (ref.)

42/54

0.9 (0.6–1.4)

2/5

0.5 (0.1–2.5)

Selenium

            

   ≤ Median

256/278

1.0 (ref.)

78/101

0.9 (0.6–1.2)

6/3

2.1 (0.5–8.6)

115/164

1.0 (ref.)

37/48

1.1 (0.7–1.8)

5/3

2.3 (0.5–9.9)

   > Median

294/285

1.0 (ref.)

101/87

1.1 (0.8–1.6)

15/9

1.7 (0.7–3.9)

163/153

1.0 (ref.)

48/54

0.9 (0.5–1.3)

2/8

0.3 (0.1–1.2)

Vitamin supplement

            

   No

488/480

1.0 (ref.)

162/174

0.9 (0.7–1.2)

20/10

1.9 (0.9–4.2)

227/255

1.0 (ref.)

70/80

1.0 (0.7–1.5)

5/10

0.6 (0.2–1.7)

   Yes

62/83

1.0 (ref.)

17/14

1.6 (0.7–3.6)

1/2

0.7 (0.1–7.8)

51/62

1.0 (ref.)

15/22

0.9 (0.4–2.0)

2/1

2.1 (0.2–24.3)

Dietary antioxidant indexc

            

   ≤ Median

262/280

1.0 (ref.)

89/98

1.0 (0.7–1.4)

7/3

2.4 (0.6–9.5)

126/161

1.0 (ref.)

43/51

1.1 (0.7–1.8)

5/3

2.2 (0.5–9.4)

   > Median

288/283

1.0 (ref.)

90/90

1.0 (0.7–1.4)

14/9

1.6 (0.7–3.8)

152/156

1.0 (ref.)

42/51

0.9 (0.5–1.4)

2/8

0.3 (0.1–1.2)

  1. aNumber of cases/controls. bAdjusted for age. cDietary antioxidant index was derived as described in the Methods section. CI, confidence interval; OR, odds ratio; ref., reference.