Skip to main content

Advertisement

Table 4 Associations of breast cancer with the manganese superoxide dismutase polymorphism polymorphism, stratified by food and nutrient intake, in the Shanghai Breast Cancer Study

From: Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study

Stratified variable Premenopausal women Postmenopausal women
  Val/Val Val/Ala Ala/Ala Val/Val Val/Ala Ala/Ala
  n a ORb (95% CI) n a ORb (95% CI) n a ORb (95% CI) n a ORb (95% CI) n a ORb (95% CI) n a ORb (95% CI)
Total vegetables             
   ≤ Median 273/290 1.0 (ref.) 89/88 1.1 (0.8–1.6) 9/4 2.4 (0.7–8.0) 145/164 1.0 (ref.) 49/44 1.3 (0.8–2.0) 4/6 0.7 (0.2–2.7)
   > Median 277/273 1.0 (ref.) 90/100 0.9 (0.6–1.2) 12/8 1.5 (0.6–3.7) 133/153 1.0 (ref.) 36/58 0.7 (0.5–1.2) 3/5 0.8 (0.2–3.3)
Total fruits             
   ≤ Median 260/281 1.0 (ref.) 95/98 1.1 (0.8–1.5) 7/3 2.6 (0.7–10.0) 152/166 1.0 (ref.) 38/44 1.0 (0.6–1.6) 4/5 1.0 (0.3–3.8)
   > Median 290/282 1.0 (ref.) 84/90 0.9 (0.6–1.2) 14/9 1.5 (0.7–3.6) 126/151 1.0 (ref.) 47/58 1.0 (0.6–1.5) 3/6 0.6 (0.1–2.3)
Vitamin A             
   ≤ Median 238/286 1.0 (ref.) 86/92 1.1 (0.8–1.6) 10/4 2.9 (0.9–9.2) 111/165 1.0 (ref.) 29/46 1.0 (0.6–1.6) 5/4 1.9 (0.5–7.3)
   > Median 312/277 1.0 (ref.) 93/96 0.9 (0.6–1.2) 11/8 1.3 (0.5–3.3) 167/152 1.0 (ref.) 55/56 0.9 (0.6–1.4) 2/7 0.3 (0.1–1.3)
Carotene             
   ≤ Median 281/287 1.0 (ref.) 88/90 1.0 (0.7–1.5) 10/4 2.6 (0.8–8.4) 131/157 1.0 (ref.) 41/52 0.9 (0.6–1.5) 3/6 0.6 (0.1–2.4)
   > Median 269/276 1.0 (ref.) 91/98 0.9 (0.7–1.3) 11/8 1.4 (0.5–3.5) 147/160 1.0 (ref.) 44/50 1.0 (0.6–1.6) 4/5 0.9 (0.2–3.4)
Vitamin E             
   ≤ Median 288/282 1.0 (ref.) 96/95 1.0 (0.7–1.4) 10/5 1.9 (0.7–5.7) 156/155 1.0 (ref.) 48/53 0.9 (0.6–1.5) 4/7 0.6 (0.2–2.1)
   > Median 262/281 1.0 (ref.) 83/93 1.0 (0.7–1.4) 11/7 1.8 (0.7–4.9) 122/162 1.0 (ref.) 37/49 1.1 (0.6–1.7) 3/4 1.0 (0.2–4.8)
Vitamin C             
   ≤ Median 275/282 1.0 (ref.) 92/96 1.0 (0.7–1.4) 12/4 3.1 (1.0–9.8) 137/161 1.0 (ref.) 43/48 1.1 (0.7–1.7) 5/6 1.0 (0.3–3.3)
   > Median 275/281 1.0 (ref.) 87/92 1.0 (0.7–1.3) 9/8 1.1 (0.4–3.0) 141/156 1.0 (ref.) 42/54 0.9 (0.6–1.4) 2/5 0.5 (0.1–2.5)
Selenium             
   ≤ Median 256/278 1.0 (ref.) 78/101 0.9 (0.6–1.2) 6/3 2.1 (0.5–8.6) 115/164 1.0 (ref.) 37/48 1.1 (0.7–1.8) 5/3 2.3 (0.5–9.9)
   > Median 294/285 1.0 (ref.) 101/87 1.1 (0.8–1.6) 15/9 1.7 (0.7–3.9) 163/153 1.0 (ref.) 48/54 0.9 (0.5–1.3) 2/8 0.3 (0.1–1.2)
Vitamin supplement             
   No 488/480 1.0 (ref.) 162/174 0.9 (0.7–1.2) 20/10 1.9 (0.9–4.2) 227/255 1.0 (ref.) 70/80 1.0 (0.7–1.5) 5/10 0.6 (0.2–1.7)
   Yes 62/83 1.0 (ref.) 17/14 1.6 (0.7–3.6) 1/2 0.7 (0.1–7.8) 51/62 1.0 (ref.) 15/22 0.9 (0.4–2.0) 2/1 2.1 (0.2–24.3)
Dietary antioxidant indexc             
   ≤ Median 262/280 1.0 (ref.) 89/98 1.0 (0.7–1.4) 7/3 2.4 (0.6–9.5) 126/161 1.0 (ref.) 43/51 1.1 (0.7–1.8) 5/3 2.2 (0.5–9.4)
   > Median 288/283 1.0 (ref.) 90/90 1.0 (0.7–1.4) 14/9 1.6 (0.7–3.8) 152/156 1.0 (ref.) 42/51 0.9 (0.5–1.4) 2/8 0.3 (0.1–1.2)
  1. aNumber of cases/controls. bAdjusted for age. cDietary antioxidant index was derived as described in the Methods section. CI, confidence interval; OR, odds ratio; ref., reference.