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Table 3 Associations of breast cancer with the manganese superoxide dismutase polymorphism, stratified by lifestyle factors, in the Shanghai Breast Cancer Study

From: Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study

Stratified variable (by median) MnSOD genotypes
  Val/Val Val/Ala Ala/Ala
  n a ORb (95% CI) n a ORb (95% CI) n a ORb (95% CI)
Premenopausal women
BMI       
   ≤ Median 250/275 1.0 (ref.) 73/99 0.9 (0.6–1.2) 8/7 1.3 (0.5–3.7)
   > Median 300/288 1.0 (ref.) 106/89 1.1 (0.8–1.6) 13/5 2.5 (0.9–7.0)
Years of menstruationc       
   ≤ Median 203/286 1.0 (ref.) 77/91 1.2 (0.8–1.7) 8/8 1.4 (0.5–3.7)
   > Median 347/277 1.0 (ref.) 102/97 0.8 (0.6–1.2) 13/4 2.6 (0.8–8.0)
Postmenopausal women
BMI       
   ≤ Median 126/156 1.0 (ref.) 39/52 1.0 (0.6–1.6) 4/7 0.7 (0.2–2.5)
   > Median 152/161 1.0 (ref.) 46/50 1.0 (0.6–1.6) 3/4 0.8 (0.2–3.7)
Years of menstruationc       
   ≤ Median 128/172 1.0 (ref.) 44/54 1.1 (0.7–1.8) 2/6 0.4 (0.1–2.2)
   > Median 150/145 1.0 (ref.) 41/48 0.8 (0.5–1.3) 5/5 1.0 (0.3–3.5)
  1. aNumber of cases/controls. bAdjusted for age. cYears of menstruation = menopausal age or age at interview for premenopausal women – menarche age. CI, confidence interval; MnSOD, manganese superoxide dismutase; OR, odds ratio; ref., reference.