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Table 2 Association between the manganese superoxide dismutase polymorphism and breast cancer risk in the Shanghai Breast Cancer Study

From: Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study

Genotype

Cases (n [%])

Controls (n [%])

ORa

95% CI

All subjects

Val/Val

831 (73.9)

884 (73.9)

1.0

Reference

Val/Ala

266 (23.6)

290 (24.2)

1.0

0.8–1.2

Ala/Ala

28 (2.5)

23 (1.9)

1.3

0.7–2.3

Val/Val and Val/Ala

1097 (97.5)

1174 (98.1)

1.0

Reference

Ala/Ala

28 (2.5)

23 (1.9)

1.3

0.7–2.3

Stratified analyses by menopausal status

Premenopausal women

    

   Val/Val and Val/Ala

729 (97.2)

751 (98.4)

1.0

Reference

   Ala/Ala

21 (2.8)

12 (1.6)

1.8

0.9–3.7

Postmenopausal women

    

   Val/Val and Val/Ala

363 (98.1)

419 (97.4)

1.0

Reference

   Ala/Ala

7 (1.9)

11 (2.6)

0.8

0.3–2.0

   

P for interaction = 0.147

 

Stratified analyses by age

Age < 45 years

    

   Val/Val and Val/Ala

442 (97.1)

488 (98.4)

1.0

Reference

   Ala/Ala

13 (2.9)

8 (1.6)

1.8

0.7–4.3

Age ≥ 45 years

    

   Val/Val and Val/Ala

655 (97.8)

686 (97.9)

1.0

Reference

   Ala/Ala

15 (2.2)

15 (2.1)

1.1

0.5–2.2

   

P for interaction = 0.380

 
  1. aAdjusted for age. CI, confidence interval; OR, odds ratio.