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Table 2 Association between the manganese superoxide dismutase polymorphism and breast cancer risk in the Shanghai Breast Cancer Study

From: Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study

Genotype Cases (n [%]) Controls (n [%]) ORa 95% CI
All subjects
Val/Val 831 (73.9) 884 (73.9) 1.0 Reference
Val/Ala 266 (23.6) 290 (24.2) 1.0 0.8–1.2
Ala/Ala 28 (2.5) 23 (1.9) 1.3 0.7–2.3
Val/Val and Val/Ala 1097 (97.5) 1174 (98.1) 1.0 Reference
Ala/Ala 28 (2.5) 23 (1.9) 1.3 0.7–2.3
Stratified analyses by menopausal status
Premenopausal women     
   Val/Val and Val/Ala 729 (97.2) 751 (98.4) 1.0 Reference
   Ala/Ala 21 (2.8) 12 (1.6) 1.8 0.9–3.7
Postmenopausal women     
   Val/Val and Val/Ala 363 (98.1) 419 (97.4) 1.0 Reference
   Ala/Ala 7 (1.9) 11 (2.6) 0.8 0.3–2.0
    P for interaction = 0.147  
Stratified analyses by age
Age < 45 years     
   Val/Val and Val/Ala 442 (97.1) 488 (98.4) 1.0 Reference
   Ala/Ala 13 (2.9) 8 (1.6) 1.8 0.7–4.3
Age ≥ 45 years     
   Val/Val and Val/Ala 655 (97.8) 686 (97.9) 1.0 Reference
   Ala/Ala 15 (2.2) 15 (2.1) 1.1 0.5–2.2
    P for interaction = 0.380  
  1. aAdjusted for age. CI, confidence interval; OR, odds ratio.