Recent translational research: microarray expression profiling of breast cancer – beyond classification and prognostic markers?

Table 2 Estrogen-regulated genes in MCF-7 breast cancer cells

Estrogen-modulated and antagonized by ICI	Number of genes from Frasor and colleagues ^a	Number of genes from Cunliffe and colleagues ^b	Number of genes shared	Gene symbols
Upregulated	25	≈164 ^c	3	WISP2, CA12, TOP2A
Downregulated	61	≈80	7	INHBB, CTSH, ERBB2, IFI30, LAMB2, SELENBP1, IL1R

^a Data extracted from Frasor and colleagues, Tables 2 and 3 [8]. ^b Data extracted from Cunliffe and colleagues, Supplementary Figure 1 [7]. ^c Frasor and colleagues, Table 6 [8] identified 51 genes unaffected by E₂ but downregulated by ICI. Of these genes, 22 (41%) are found in the set of 164 genes upregulated by E₂ and downregulated by ICI in the Cunliffe and colleagues experiments, indicating that the response to ICI for these 22 genes was the same in both studies although the E₂ response differed.

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