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Table 4 Comparison of age strata with tumor histologic grade, immunohistochemistry and chromogenic in situ hybridization results

From: Chromogenic in situ hybridization (CISH): a novel alternative in screening archival breast cancer tissue samples for HER-2/neu status

Parameter Age <50 Age ≥ 50 Total
Immunohistochemistry    
   Negative (0 and 1+) 33 (41.25%) 47 (58.75%) 80
   Positive (2+ and 3+) 41 (51.25%) 39 (48.75%) 80
   Total 74 86 160
Chromogenic in situ hybridization    
   No amplification 43 (42.16%) 59 (57.84%) 102
   With amplification 31 (53.44%) 27 (46.55%) 58
   Total 74 86 160
Histologic grade    
   1 0 (0.00%) 4 (100.00%) 4
   2 53 (47.32%) 59 (52.68%) 112
   3 21 (47.73%) 23 (52.23%) 44
   Total 74 86 160