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Table 4 Comparison of age strata with tumor histologic grade, immunohistochemistry and chromogenic in situ hybridization results

From: Chromogenic in situ hybridization (CISH): a novel alternative in screening archival breast cancer tissue samples for HER-2/neu status

Parameter

Age <50

Age ≥ 50

Total

Immunohistochemistry

   

   Negative (0 and 1+)

33 (41.25%)

47 (58.75%)

80

   Positive (2+ and 3+)

41 (51.25%)

39 (48.75%)

80

   Total

74

86

160

Chromogenic in situ hybridization

   

   No amplification

43 (42.16%)

59 (57.84%)

102

   With amplification

31 (53.44%)

27 (46.55%)

58

   Total

74

86

160

Histologic grade

   

   1

0 (0.00%)

4 (100.00%)

4

   2

53 (47.32%)

59 (52.68%)

112

   3

21 (47.73%)

23 (52.23%)

44

   Total

74

86

160