Relationships between p14ARF and Hdm2 localisation and overall survival. Overall survival curves according to nuclear p14ARF (a), cytoplasmic p14ARF (b) and cytoplasmic Hdm2 (c), with patient numbers and deaths in parentheses. The classification of 'present' or 'absent' p14ARF or Hdm2 expression was determined by an MQS of 3 or more to define positivity, compared with an MQS of <3 to define absent expression. Patient numbers reflect the exclusion of six local tumour recurrences from the analysis of patient outcome and include only recorded deaths in 23 patients. P values are given for the log ranks that reached significance.