Figure 4

Genomic copy number profiles of cell lines. Array comparative genomic hybridization analysis was performed on a panel of human breast cancer cells in order to map the DNA sequence copy number variation throughout the entire genome. The data are plotted as the log₂ ratio for each BAC clone ordered across the genome from 1pter to Xqter. The reference DNA was male. The SUM185 cell lines (a) and SUM149PT cell lines (b) showed many copy number changes, while other breast cancer cells such as SUM159 cell lines (c) and SUM225 cell lines (d) had a basically normal genome with a few low-level copy number changes and focal amplifications.