TY - JOUR AU - Willmarth, Nicole E. AU - Albertson, Donna G. AU - Ethier, Stephen P. PY - 2004 DA - 2004/07/06 TI - Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells JO - Breast Cancer Research SP - R531 VL - 6 IS - 5 AB - Cyclin E, a G1 cyclin essential for G1–S phase transition, is known to have a profound effect on tumorigenesis. Elevated levels of cyclin E have been associated with breast cancer, and chromosomal instability observed in breast cancer is suggested to be associated with constitutive expression of cyclin E. It was previously demonstrated that SUM149PT human breast cancer cells show very high levels of cyclin E expression by western analysis and that they express a nonfunctional cyclin E ubiquitin ligase due to a mutation in the F-box protein hCdc4. SN - 1465-542X UR - https://doi.org/10.1186/bcr900 DO - 10.1186/bcr900 ID - Willmarth2004 ER -