Polymorphic repeat in AIB1 does not alter breast cancer risk

Breast Cancer Research

Table 2 Association of AIB1 genotype and breast cancer risk, Nurses' Health Study 1989-1994

Premenopausal	Cases	Controls	OR^*	95% CI
No of alleles with 26 or fewer repeats
0	49	51	1.00
1	14	16	0.91	0.40-2.09
2	1	3	0.32	0.03-3.25
1 or 2	15	19	0.82	0.37-1.81
Postmenopausal	Cases	Controls	OR^†	95% CI
No of alleles with 26 or fewer repeats
0	275	397	1.00
1	75	106	1.04	0.74-1.46
2	8	7	1.90	0.67-5.42
1 or 2	83	113	1.09	0.78-1.52
Combined analysis	Cases	Controls^‡	OR^§	95% CI
No of alleles with 26 or fewer repeats
0	361	476	1.00
1	94	129	0.99	0.73-1.35
2	9	10	1.29	0.52-3.23
1 or 2	103	139	1.01	0.75-1.36
AIB1 genotype^¶
29/29	92	141	1.00
28/29	196	227	1.27	0.91-1.77
28/28	64	95	0.99	0.65-1.50
26/29	47	69	1.04	0.66-1.64
26/28	45	55	1.23	0.75-2.02
26/26	9	10	1.48	0.57-3.81

^*Unconditional logistic regression adjusted for the matching variables: age, date of blood sampling, time of blood sampling and fasting status. ^†Unconditional logistic regression adjusted for the matching variables: age, postmenopausal hormone use, date of blood sampling, time of blood sampling and fasting status. ^‡Nine controls were excluded due to incomplete matching. ^§Conditional logistic regression adjusted for the matching variables: age, menopausal status, postmenopausal hormone use, date of blood sampling, time of blood sampling and fasting status. ^¶Genotypes combined and modeled together, but not included in table (cases, controls): 19/29 (0, 1), 22/29 (0, 1), 25/28 (0, 1), 25/29 (1, 0), 26/30 (1, 2), 27/28 (2, 1), 27/29 (1, 2), 28/30 (2, 3), 28/31 (1, 1), 28/34 (1, 0), 29/30 (1, 5), and 29/31 (1, 1).

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