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Table 2 UGT1A1, UGT2B4, UGT2B7, UBT2B15, and SULT1A1 genotypes and risk of ER- and PR- breast tumors in Caucasian and Asian female breast cancer patients, Washington state

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Gene ER+
n
ER-
n
ORa
ER-tumor
Combinedb PR+
n
PR-
n
ORa
PR-tumor
Combinedb
UGT1A1         
   (TA)6/(TA)6 53 21 1.0 (ref) 1.0 (ref) 57 17 1.0 (ref) 1.0 (ref)e
   (TA)6/(TA)7 55 16 0.6 (0.2–1.3)   55 16 1.1 (0.5–2.6)  
   (TA)7/(TA)7 10 0 0.0 (0.0–0.5)* 0.5 (0.2–1.1)d 9 1 0.3 (0.02–2.6) 0.2 (0.02–2.4)
UGT2B4         
   Asp/Asp 78 21 1.0 (ref) 1.0 (ref) 81 18 1.0 (ref)  
   Asp/Glu 30 13 1.5 (0.6–3.6)   30 13 2.2 (0.9–5.4)  
   Glu/Glu 10 3 1.3 (0.3–5.9) 1.5 (0.6–3.3)d 10 3 0.9 (0.2–4.5)  
UGT2B7         
   His/His 31 9 1.0 (ref)   33 7 1.0 (ref)  
   His/Tyr 58 12 0.6 (0.2–1.7)   52 18 1.5 (0.5–4.5)  
   Tyr/Tyr 29 16 1.8 (0.6–5.2)   36 9 1.4 (0.4–4.5)  
UGT2B15         
   Asp/Asp 20 10 1.0 (ref) 1.0 (ref) 25 5 1.0 (ref)  
   Asp/Tyr 61 19 0.5 (0.2–1.4)   59 21 1.3 (0.4–4.1)  
   Tyr/Tyr 37 8 0.4 (0.1–1.2) 0.5 (0.2–1.2)d 37 8 0.6 (0.2–2.4)  
SULT1A1         
   Arg/Arg 49 19 1.0 (ref) 1.0 (ref) 52 16 1.0 (ref) 1.0 (ref)
   Arg/His 50 13 0.6 (0.2–1.3)   50 13 0.9 (0.4–2.2)  
   His/His 19 5 0.6 (0.2–1.9) 0.6 (0.3–1.2)d 19 5 0.8 (0.2–2.6) 0.9 (0.4–2.0)d
  1. ER, estrogen receptor; OR, odds ratio; PR, progesterone receptor. aAdjusted for age, menopausal status, age at menarche, number of pregnancies lasting at least 6 months (0, 1, 2, or 3 or more), parity/age at first birth (nulliparous, age at first birth 26 or less, age at first birth more than 26), weight change since age 18, race (Asian/Caucasian), smoking, and number of ovaries remaining. bGenotypes were also evaluated with the use of dichotomous variables ('any wild-type allele' [wild-type and heterozygous individuals] and 'any variant allele' [heterozygous and homozygous variant individuals]) when patterns suggested a dominant or recessive genotype effect. cP for trend = 0.03. dOR for combined group of heterozygous and homozygous variant individuals. eOR for combined group of wild type and heterozygous individuals.