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Table 1 Selected characteristics of the Caucasian and Asian women enrolled in the Health, Eating, Activity, and Lifestyle study and asubpopulation used for investigating associations with circulating sex hormones at the 24-month follow-up

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Characteristic Baseline (n = 163) Subpopulation at 24-month follow-upa (n = 89)
  n (%) n (%)
Age at enrollment, years 52.4 (6.5)b 57.3 (5.7)b
   40–49 59 (36) 10 (11)
   50–59 75 (46) 43 (48)
   60–69 29 (18) 36 (40)
Race   
   Caucasian 150 (92) 82 (92)
   Asian 13 (8) 7 (8)
Number of pregnancies   
lasting at least 6 months   n/a
   0 31 (19)  
   1 27 (17)  
   2 59 (36)  
   3+ 45 (28)  
Weight change since age 18 (kg) +15.8 (14.4)b n/a
Body fat (%) n/a 36.8 (5.5)b
Tumor receptor status   
   ER+ tumor 124 (76) n/a
   PR+ tumor 128 (79) n/a
   ER+/PR+ tumor 107 (66) n/a
   ER+/PR tumor 17 (10)  
   ER /PR+ tumor 21 (13)  
   ER /PR tumor 18 (11)  
Stage of disease   
   0, in situ 51 (31) n/a
   I 83 (51)  
   II 29 (18)  
Subject genotypes   
   UGT1A1 genotypes (TA)6/(TA)7   
   (TA)6/(TA)6 80 (49) 49 (55)
   (TA)6/(TA)7 72 (44) 36 (40)
   (TA)7/(TA)7 11 (7) 4 (5)
   (TA)7 allele frequency 0.29 0.25
UGT2B4 genotypes (Asp458Glu)   
   Asp/Asp 104 (64) 53 (60)
   Asp/Glu 46 (28) 29 (33)
   Glu/Glu 13 (8) 7 (8)
   Glu allele frequency 0.22 0.24
UGT2B7 genotypes (His268Tyr)   
   His/His 41 (25) 24 (27)
   His/Tyr 73 (45) 48 (54)
   Tyr/Tyr 49 (30) 17 (19)
   Tyr allele frequency 0.52 0.46
UGT2B15 genotypes (Asp85Tyr)   
   Asp/Asp 32 (20) 19 (21)
   Asp/Tyr 83 (51) 47 (53)
   Tyr/Tyr 48 (29) 23 (26)
   Tyr allele frequency 0.55 0.52
SULT1A1 genotypes (Arg213His)   
   Arg/Arg 71 (43) 39 (44)
   Arg/His 68 (42) 38 (43)
   His/His 24 (15) 12 (13)
   His allele frequency 0.36 0.35
  1. ER, estrogen receptor; n/a, not applicable; PR, progesterone receptor. aRestricted to postmenopausal women not taking estrogen or progesterone therapy at the time of blood draw for investigation of associations between genotype and sex hormone concentrations. bMean (SD).