| |
Genotype
|
Overall
|
Premenopausal
|
Postmenopausal
|
|---|
| | |
Cases/controls
|
OR (95% CI)a
|
ICR (95% CI)
|
Cases/controls
|
OR (95% CI)a
|
ICR (95% CI)
|
Cases/controls
|
OR (95% CI)a
|
ICR (95% CI)
|
|---|
|
Active smoking status
| | | | | | | | | | |
|
Never
|
wt/wtb
|
252/256
|
Reference
| |
132/120
|
Reference
| |
120/136
|
Reference
| |
|
Never
|
M1 variantc
|
96/115
|
0.8 (0.6–1.2)
| |
46/47
|
0.9 (0.5–1.4)
| |
50/68
|
0.8 (0.5–1.3)
| |
|
Former
|
wt/wt
|
143/129
|
1.2 (0.9–1.6)
| |
62/53
|
1.0 (0.7–1.6)
| |
81/76
|
1.3 (0.9–1.9)
| |
|
Former
|
M1 variant
|
65/47
|
1.4 (0.9–2.2)
|
+0.4 (-0.2, 1.1)
|
37/26
|
1.3 (0.7–2.2)
|
+0.4 (-0.5, 1.2)
|
28/21
|
1.5 (0.8–2.9)
|
+0.5 (-0.5, 1.5)
|
|
Current
|
wt/wt
|
87/105
|
0.8 (0.6–1.2)
| |
48/48
|
0.9 (0.5–1.4)
| |
39/57
|
0.8 (0.5–1.3)
| |
|
Current
|
M1 variant
|
35/43
|
0.9 (0.5–1.4)
| |
20/25
|
0.7 (0.4–1.4)
| |
15/18
|
1.0 (0.5–2.1)
| |
|
Number of cigarettes (pack/day)
| | | | | | | | | | |
|
Never
|
wt/wtb
|
252/256
|
Reference
| |
132/120
|
Reference
| |
120/136
|
Reference
| |
|
Never
|
M1 variantc
|
96/115
|
0.8 (0.6–1.2)
| |
46/47
|
0.9 (0.5–1.4)
| |
50/68
|
0.8 (0.5–1.3)
| |
|
≤ 1
|
wt/wt
|
159/159
|
1.0 (0.8–1.4)
| |
76/70
|
1.0 (0.6–1.4)
| |
83/89
|
1.1 (0.7–1.6)
| |
|
≤ 1
|
M1 variant
|
71/64
|
1.2 (0.8–1.7)
| |
43/38
|
1.0 (0.6–1.7)
| |
28/26
|
1.3 (0.7–2.3)
| |
|
> 1
|
wt/wt
|
68/74
|
1.0 (0.7–1.4)
| |
32/30
|
0.9 (0.5–1.6)
| |
36/44
|
1.0 (0.6–1.7)
| |
|
> 1
|
M1 variant
|
29/26
|
1.2 (0.7–2.1)
|
+0.4 (-0.4, 1.1)
|
14/13
|
1.0 (0.4–2.2)
|
+0.1 (-0.9, 1.1)
|
15/13
|
1.4 (0.6–3.0)
|
+0.6 (-0.6, 1.7)
|
|
Duration of smoking
| | | | | | | | | | |
|
Never
|
wt/wtb
|
252/256
|
Reference
| |
132/120
|
Reference
| |
120/136
|
Reference
| |
|
Never
|
M1 variantc
|
96/115
|
0.8 (0.6–1.2)
| |
46/47
|
0.9 (0.5–1.4)
| |
50/68
|
0.8 (0.5–1.3)
| |
|
≤ 20 years
|
wt/wt
|
119/127
|
0.9 (0.7–1.2)
| |
80/77
|
0.9 (0.6–1.3)
| |
39/50
|
0.9 (0.6–1.5)
| |
|
≤ 20 years
|
M1 variant
|
51/57
|
0.9 (0.6–1.3)
| |
37/39
|
0.8 (0.5–1.4)
| |
14/18
|
0.9 (0.4–1.7)
| |
|
> 20 years
|
wt/wt
|
110/106
|
1.2 (0.9–1.6)
| |
30/23
|
1.2 (0.7–2.2)
| |
80/83
|
1.2 (0.8–1.7)
| |
|
> 20 years
|
M1 variant
|
49/33
|
1.7 (1.1–2.8)
|
+0.7 (-0.2, 1.6)
|
20/12
|
1.5 (0.7–3.3)
|
+0.5 (-0.7, 3.8)
|
29/21
|
1.7 (0.9–3.1)
|
+0.7 (-1.4, 5.3)
|
|
Time since cessation
| | | | | | | | | | |
|
Never
|
wt/wtb
|
252/256
|
Reference
| |
132/120
|
Reference
| |
120/136
|
Reference
| |
|
Never
|
M1 variantc
|
96/115
|
0.8 (0.6–1.2)
| |
46/47
|
0.9 (0.5–1.4)
| |
50/68
|
0.8 (0.5–1.3)
| |
|
< 10 years
|
wt/wt
|
76/53
|
1.5 (1.0–2.2)
| |
33/24
|
1.1 (0.6–2.0)
| |
43/29
|
1.8 (1.0–3.0)
| |
|
< 10 years
|
M1 variant
|
41/14
|
3.0 (1.6–5.7)
|
+1.7 (-0.7, 3.8)
|
23/8
|
2.4 (1.0–5.7)
|
+1.6 (-0.7, 3.8)
|
18/6
|
3.6 (1.4–9.4)
|
+2.0 (-1.4, 5.3)
|
|
≥ 10 years
|
wt/wt
|
67/76
|
1.0 (0.7–1.5)
| |
29/29
|
0.9 (0.5–1.7)
| |
38/47
|
1.0 (0.6–1.6)
| |
|
≥ 10 years
|
M1 variant
|
24/33
|
0.8 (0.4–1.3)
| |
14/18
|
0.7(0.3–1.5)
| |
10/15
|
0.7 (0.3–1.7)
| |
|
Age started smoking
| | | | | | | | | | |
|
Never
|
wt/wtb
|
252/256
|
Reference
| |
132/120
|
Reference
| |
120/136
|
Reference
| |
|
Never
|
M1 variantc
|
96/115
|
0.8 (0.6–1.2)
| |
46/47
|
0.9 (0.5–1.4)
| |
50/68
|
0.8 (0.5–1.3)
| |
|
< 18 years
|
wt/wt
|
87/84
|
1.0 (0.7–1.5)
| |
45/44
|
0.8 (0.5–1.4)
| |
42/40
|
1.3 (0.8–2.1)
| |
|
< 18 years
|
M1 variant
|
35/25
|
1.4 (0.8–2.4)
|
+0.5 (-0.3, 1.4)
|
24/12
|
1.6 (0.8–3.4)
|
+0.9 (-0.4, 2.2)
|
11/13
|
1.0 (0.4–2.4)
|
-0.1 (-1.1, 1.0)
|
|
≥ 18 years
|
wt/wt
|
143/150
|
1.0 (0.8–14)
| |
65/57
|
1.0 (0.7–1.6)
| |
78/93
|
1.0 (0.7–1.5)
| |
|
≥ 18 years
|
M1 variant
|
65/65
|
1.1 (0.7–1.6)
| |
33/39
|
0.8 (0.5–1.4)
| |
32/26
|
1.4 (0.8–2.6)
| |
- CI, confidence interval. a Adjusted for age, race, and sampling fractions. b wt = wild-type homozygote genotype. c M1 variant = M1/M1 or M1/wt genotypes.
