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Table 8 Odds ratios (ORs) for breast cancer according to cigarette smoking and the CYP1A1 genotype at the M1 locus, according to menopausal status (African-American and white women combined), additive scale and interaction contrast ratios

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  Genotype Overall Premenopausal Postmenopausal
   Cases/controls OR (95% CI)a ICR (95% CI) Cases/controls OR (95% CI)a ICR (95% CI) Cases/controls OR (95% CI)a ICR (95% CI)
Active smoking status           
   Never wt/wtb 252/256 Reference   132/120 Reference   120/136 Reference  
   Never M1 variantc 96/115 0.8 (0.6–1.2)   46/47 0.9 (0.5–1.4)   50/68 0.8 (0.5–1.3)  
   Former wt/wt 143/129 1.2 (0.9–1.6)   62/53 1.0 (0.7–1.6)   81/76 1.3 (0.9–1.9)  
   Former M1 variant 65/47 1.4 (0.9–2.2) +0.4 (-0.2, 1.1) 37/26 1.3 (0.7–2.2) +0.4 (-0.5, 1.2) 28/21 1.5 (0.8–2.9) +0.5 (-0.5, 1.5)
   Current wt/wt 87/105 0.8 (0.6–1.2)   48/48 0.9 (0.5–1.4)   39/57 0.8 (0.5–1.3)  
   Current M1 variant 35/43 0.9 (0.5–1.4)   20/25 0.7 (0.4–1.4)   15/18 1.0 (0.5–2.1)  
Number of cigarettes (pack/day)           
   Never wt/wtb 252/256 Reference   132/120 Reference   120/136 Reference  
   Never M1 variantc 96/115 0.8 (0.6–1.2)   46/47 0.9 (0.5–1.4)   50/68 0.8 (0.5–1.3)  
   ≤ 1 wt/wt 159/159 1.0 (0.8–1.4)   76/70 1.0 (0.6–1.4)   83/89 1.1 (0.7–1.6)  
   ≤ 1 M1 variant 71/64 1.2 (0.8–1.7)   43/38 1.0 (0.6–1.7)   28/26 1.3 (0.7–2.3)  
   > 1 wt/wt 68/74 1.0 (0.7–1.4)   32/30 0.9 (0.5–1.6)   36/44 1.0 (0.6–1.7)  
   > 1 M1 variant 29/26 1.2 (0.7–2.1) +0.4 (-0.4, 1.1) 14/13 1.0 (0.4–2.2) +0.1 (-0.9, 1.1) 15/13 1.4 (0.6–3.0) +0.6 (-0.6, 1.7)
Duration of smoking           
   Never wt/wtb 252/256 Reference   132/120 Reference   120/136 Reference  
   Never M1 variantc 96/115 0.8 (0.6–1.2)   46/47 0.9 (0.5–1.4)   50/68 0.8 (0.5–1.3)  
   ≤ 20 years wt/wt 119/127 0.9 (0.7–1.2)   80/77 0.9 (0.6–1.3)   39/50 0.9 (0.6–1.5)  
   ≤ 20 years M1 variant 51/57 0.9 (0.6–1.3)   37/39 0.8 (0.5–1.4)   14/18 0.9 (0.4–1.7)  
   > 20 years wt/wt 110/106 1.2 (0.9–1.6)   30/23 1.2 (0.7–2.2)   80/83 1.2 (0.8–1.7)  
   > 20 years M1 variant 49/33 1.7 (1.1–2.8) +0.7 (-0.2, 1.6) 20/12 1.5 (0.7–3.3) +0.5 (-0.7, 3.8) 29/21 1.7 (0.9–3.1) +0.7 (-1.4, 5.3)
Time since cessation           
   Never wt/wtb 252/256 Reference   132/120 Reference   120/136 Reference  
   Never M1 variantc 96/115 0.8 (0.6–1.2)   46/47 0.9 (0.5–1.4)   50/68 0.8 (0.5–1.3)  
   < 10 years wt/wt 76/53 1.5 (1.0–2.2)   33/24 1.1 (0.6–2.0)   43/29 1.8 (1.0–3.0)  
   < 10 years M1 variant 41/14 3.0 (1.6–5.7) +1.7 (-0.7, 3.8) 23/8 2.4 (1.0–5.7) +1.6 (-0.7, 3.8) 18/6 3.6 (1.4–9.4) +2.0 (-1.4, 5.3)
   ≥ 10 years wt/wt 67/76 1.0 (0.7–1.5)   29/29 0.9 (0.5–1.7)   38/47 1.0 (0.6–1.6)  
   ≥ 10 years M1 variant 24/33 0.8 (0.4–1.3)   14/18 0.7(0.3–1.5)   10/15 0.7 (0.3–1.7)  
Age started smoking           
   Never wt/wtb 252/256 Reference   132/120 Reference   120/136 Reference  
   Never M1 variantc 96/115 0.8 (0.6–1.2)   46/47 0.9 (0.5–1.4)   50/68 0.8 (0.5–1.3)  
   < 18 years wt/wt 87/84 1.0 (0.7–1.5)   45/44 0.8 (0.5–1.4)   42/40 1.3 (0.8–2.1)  
   < 18 years M1 variant 35/25 1.4 (0.8–2.4) +0.5 (-0.3, 1.4) 24/12 1.6 (0.8–3.4) +0.9 (-0.4, 2.2) 11/13 1.0 (0.4–2.4) -0.1 (-1.1, 1.0)
   ≥ 18 years wt/wt 143/150 1.0 (0.8–14)   65/57 1.0 (0.7–1.6)   78/93 1.0 (0.7–1.5)  
   ≥ 18 years M1 variant 65/65 1.1 (0.7–1.6)   33/39 0.8 (0.5–1.4)   32/26 1.4 (0.8–2.6)  
  1. CI, confidence interval. a Adjusted for age, race, and sampling fractions. b wt = wild-type homozygote genotype. c M1 variant = M1/M1 or M1/wt genotypes.
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