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Table 7 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M4 locus (white women only)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  M4 genotypesa wt genotypeb
  Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c
Active smoking status     
   Never 24/16 Reference 177/190 Reference
   Former 13/8 1.2 (0.4–3.6) 123/116 1.1 (0.8–1.6)
   Current 2/16 0.1 (0.0–0.4) 78/71 1.2 (0.8–1.7)
Number of cigarettes (pack/day)     
   Never 24/16 Reference 177/190 Reference
   ≤ 1 8/14 0.4 (0.1–1.2) 128/111 1.2 (0.9–1.7)
   > 1 7/10 0.5 (0.2–1.6) 71/75 1.0 (0.7–1.5)
Duration of smoking     
   Never 24/16 Reference 177/190 Reference
   ≤ 20 years 11/12 0.6 (0.2–1.8) 100/104 0.9 (0.6–1.3)
   > 20 years 4/12 0.2 (0.1–0.9) 101/83 1.5 (1.0–2.1)
Former smokers: time since cessation of smoking     
   Never 24/16 Reference 177/190 Reference
   < 10 years 6/3 1.4 (0.3–6.6) 67/48 1.4 (0.9–2.2)
   ≥ 10 years 7/5 1.0 (0.3–3.8) 56/68 0.9 (0.6–1.4)
Age started smoking     
   Never 24/16 Reference 177/190 Reference
   < 18 years 7/9 0.5 (0.2–1.8) 71/66 1.1 (0.7–1.6)
   ≥ 18 years 8/15 0.4 (0.1–1.1) 130/121 1.2 (0.9–1.7)
  1. CI, confidence interval; wt, wild type. a M4/M4 and M4/wt genotypes. b wt/wt genotype. cAdjusted for age, race, and sampling fractions.