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Table 6 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M3 locus (African-American women only)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  M3 genotypesa wt genotypeb
  Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c
Active smoking status     
   Never 24/32 Referent 124/134 Reference
   Former 16/11 1.9 (0.7–4.8) 58/42 1.7 (1.1–2.7)
   Current 7/10 0.9 (0.7–2.8) 36/51 0.8 (0.5–1.3)
Number of cigarettes (pack/day)     
   Never 24/32 Referent 124/134 Reference
   ≤ 1 18/16 1.5 (0.6–3.5) 79/82 1.2 (0.8–1.7)
   > 1 5/5 1.2 (0.3–4.7) 14/11 1.6 (0.7–3.8)
Duration of smoking     
   Never 24/32 Referent 124/134 Reference
   ≤ 20 years 8/13 0.8 (0.3–2.2) 54/55 1.2 (0.7–1.8)
   > 20 years 15/8 2.5 (0.9–7.1) 39/37 1.3 (0.8–2.2)
Former smokers: time since cessation of smoking     
   Never 24/32 Referent 124/134 Reference
   < 10 years 13/4 4.2 (1.2–14.6) 32/13 3.1 (1.5–6.1)
   ≥ 10 years 3/7 0.5 (0.1–2.3) 26/29 1.1 (0.6–2.0)
Age started smoking     
   Never 24/32 Referent 124/134 Reference
   < 18 years 12/6 2.4 (0.8–7.5) 33/29 1.3 (0.7–2.3)
   ≥ 18 years 11/15 1.0 (0.4–2.5) 61/64 1.2 (0.8–1.8)
  1. CI, confidence interval; wt, wild type. a M3/M3 and M3/wt genotypes. b wt/wt genotype. cAdjusted for age and sampling fractions.