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Table 4 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M1 locus, according to menopausal status (White and African-American women combined)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  All participants Premenopausal Postmenopausal
  M1 genotypea wt genotypeb M1 genotype wt genotype M1 genotype wt genotype
  Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c Cases/controls OR (95% CI)c
Active smoking status             
   Never 96/115 Reference 252/256 Reference 46/47 Reference 132/120 Reference 50/68 Reference 120/136 Reference
   Former 65/47 1.7 (1.1–2.8) 143/129 1.2 (0.9–1.6) 37/26 1.5 (0.8–2.9) 62/53 1.0 (0.7–1.6) 28/21 1.9 (1.0–3.8) 81/76 1.3 (0.9–1.9)
   Current 35/43 1.1 (0.6–1.8) 87/105 0.8 (0.6–1.2) 20/25 0.8 (0.4–1.7) 48/48 0.9 (0.6–1.4) 15/18 1.2 (0.6–2.7) 39/57 0.8 (0.5–1.3)
Number of cigarettes smoked (pack/day)             
   Never 96/115 Reference 252/256 Reference 46/47 Reference 132/120 Reference 50/58 Reference 120/136 Reference
   ≤ 1 71/64 1.4 (0.9–2.2) 159/159 1.0 (0.8–1.4) 43/38 1.2 (0.6–2.2) 76/70 1.0 (0.6–1.5) 28/26 1.6 (0.8–3.0) 83/89 1.1 (0.7–1.6)
   >1 29/26 1.4 (0.8–2.7) 68/74 1.0 (0.7–1.4) 14/13 1.1 (0.5–2.7) 32/30 0.9 (0.5–1.7) 15/13 1.7 (0.7–4.0) 36/44 1.0 (0.6–1.6)
Duration of smoking             
   Never 96/115 Reference 252/256 Reference 46/47 Reference 132/120 Reference 50/58 Reference 120/136 Reference
   ≤ 20 years 51/57 1.0 (0.6–1.7) 119/127 0.9 (0.7–1.3) 37/39 1.0 (0.5–1.8) 80/77 0.9 (0.6–1.4) 14/18 1.1 (0.5–2.4) 39/50 0.9 (0.6–1.5)
   > 20 years 49/33 2.1 (1.2–3.5) 110/106 1.2 (0.9–1.6) 20/12 1.9 (0.8–4.4) 30/23 1.2 (0.7–2.2) 29/21 2.1 (1.0–4.1) 80/83 1.2 (0.8–1.7)
Former smokers: time since cessation of smoking             
   Never 96/115 Reference 252/256 Reference 46/47 Reference 132/120 Reference 50/58 Reference 120/136 Reference
   < 10 years 41/14 3.7 (1.9–7.3) 76/53 1.5 (1.0–2.2) 23/8 2.9 (1.2–7.3) 33/24 1.1 (0.6–2.1) 18/6 4.6 (1.7–12.5) 43/29 1.8 (1.0–3.0)
   ≥ 10 years 24/33 1.0 (0.5–1.7) 67/76 1.0 (0.7–1.4) 14/18 0.8 (0.4–2.0) 29/29 0.9 (0.5–1.7) 10/15 0.9 (0.4–2.3) 38/47 1.0 (0.6–1.6)
Age started of smoking             
   Never 96/115 Reference 252/256 Reference 46/47 Reference 132/120 Reference 50/58 Reference 120/136 Reference
   <18 years 35/25 1.7 (0.9–3.0) 87/84 1.0 (0.7–1.5) 24/12 1.9 (0.8–4.3) 45/44 0.9 (0.5–1.4) 11/13 1.2 (0.5–3.0) 42/40 1.2 (0.8–2.1)
   ≥ 18 years 65/65 1.3 (0.9–2.1) 143/150 1.0 (0.8–1.4) 33/39 0.9 (0.5–1.7) 65/57 1.1 (0.7–1.7) 32/26 1.8 (0.9–3.4) 78/93 1.0 (0.7–1.5)
Exposure to ETS             
   Unexposed to active smoking or ETS after age 18 36/48 Reference 95/84 Reference 20/29 Reference 56/51 Reference 16/19 Reference 39/33 Reference
   ETS after age 18 60/67 1.4 (0.8–2.5) 156/172 0.9 (0.7–1.4) 26/18 2.5 (1.0–6.1) 76/69 1.2 (0.7–2.0) 34/49 0.7 (0.3–1.7) 80/103 0.7 (0.4–1.2)
  1. CI, confidence interval; wt, wild type; ETS, environmental tobacco smoke. a M1/M1 and M1/wt genotypes. b wt/wt genotype. cAdjusted for age, race, and sampling fractions.