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Table 3 Odds ratios (ORs) for breast cancer in relation to CYP1A1 genotypes, according to menopausal status (African-American and white women combined)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  Premenopausal Postmenopausal
  Cases (n = 352) Controls (n = 321) OR (95% CI)a Cases (n = 336) Controls (n = 381) OR (95% CI)a
M1 locus       
   wt/wt 242 221 Reference 240 269 Reference
   M1/wt 88 87 1.0 (0.7–1.4) 83 98 0.9 (0.7–1.3)
   M1/M1 15 11 1.2 (0.6–2.8) 10 9 1.2 (0.5–3.0)
   M1/wt or M1/M1 103 98 1.0 (0.7–1.4) 93 107 1.0 (0.7–1.3)
   Missing 7 2 3 5   
M2 locus       
   wt/wt 329 294 Reference 315 358 Reference
   M2/wt 21 25 0.7 (0.4–1.3) 20 23 1.0 (0.6–1.9)
   M2/M2 2 2 0.9 (0.1–6.3)b 1 0 nd
   M2/wt or M2/M2 23 27 0.7 (0.4–1.3) 21 23 1.1 (0.6–2.0)
   Missing 0 0 0 0   
M3 locus       
   wt/wt 327 296 Reference 303 344 Reference
   M3/wt 18 20 0.9 (0.4–1.8) 30 28 1.2 (0.7–2.2)
   M3/M3 0 3 nd 0 4 nd
   M3/wt or M3/M3 18 23 0.8 (0.4–1.5) 30 32 1.0 (0.6–1.8)
   Missing 7 2 3 5   
M4 locus       
   wt/wt 325 301 Reference 320 354 Reference
   M4/wt 27 20 1.3 (0.7–2.3) 14 27 0.6 (0.3–1.1)
   M4/M4 0 0 nd 2 0 nd
   M4/wt or M4/M4 27 20 1.3 (0.7–2.3) 16 27 0.7 (0.4–1.3)
   Missing 0 0 0 0   
  1. CI, confidence interval; wt, wild type; nd, not determined. a Adjusted for age, race, and sampling fractions. b Imprecise estimate.