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Table 2 Odds ratios (ORs) for breast cancer in relation to the CYP1A1 genotypes, in African-American and white women

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  Overall African Americans Whites
  Cases Controls OR (95% CI)a Cases Controls OR (95% CI)b Cases Controls OR (95% CI)b
M1 locus          
   wt/wt 482 490 Reference 155 165 Reference 327 325 Reference
   M1/wt 171 185 1.0 (0.7–1.2) 93 102 1.0 (0.7–1.4) 78 83 0.9 (0.7–1.3)
   M1/M1 25 20 1.2 (0.7–2.3) 17 13 1.3 (0.6–2.8) 8 7 1.1 (0.4–3.2)
   M1/wt or M1/M1 196 205 1.0 (0.8–1.2) 110 115 1.0 (0.7–1.4) 86 90 1.0 (0.7–1.3)
   Missing 10 7 6 5 4 2    
M2 locus          
   wt/wt 644 652 Reference 259 274 Reference 385 378 Reference
   M2/wt 41 48 0.8 (0.5–1.3) 12 11 1.0 (0.4–2.4) 29 37 0.8 (0.5–1.3)
   M2/M2 3 2 1.3 (0.2–7.7)c 0 0 nd 3 2 1.3 (0.2–8.2)c
   M2/wt or M2/M2 44 50 0.9 (0.6–1.3) 12 11 1.0 (0.4–2.4) 32 39 0.8 (0.5–1.3)
   Missing 0 0 0 0 0 0    
M3 locus          
   wt/wt 630 640 Reference 218 227 Reference 412 413 Reference
   M3/wt 48 48 1.1 (0.7–1.7) 47 47 1.1 (0.7–1.7) 1 1 0.7 (0.0–11.4)c
   M3/M3 0 7 nd 0 6 nd 0 1 nd
   M3/wt or M3/M3 48 55 0.9 (0.6–1.4) 47 53 1.0 (0.6–1.5) 1 2 0.4 (0.0–4.0)c
   Missing 10 7 6 5 4 2    
M4 locus          
   wt/wt 645 655 Reference 267 278 Reference 378 377 Reference
   M4/wt 41 47 0.9 (0.6–1.4) 3 7 0.5 (0.1–1.8)c 38 40 1.0 (0.6–1.6)
   M4/M4 2 0 nd 1 0 nd 1 0 nd
   M4/wt or M4/M4 43 47 0.9 (0.6–1.4) 4 7 0.6 (0.2–2.0)c 39 40 1.0 (0.6–1.6)
   Missing 0 0 0 0 0 0    
  1. CI, confidence interval; wt, wild type; nd, not determined. a Adjusted for age, race, and sampling fractions. b Adjusted for age and sampling fractions. c Imprecise estimate.