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Table 1 Genotype frequencies for CYP1A1 among African-American and white participants in the Carolina Breast Cancer Study (1993–1996)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

  African-Americans Whites
  Cases (n = 271) Controls (n = 285) Cases (n = 417) Controls (n = 417)
M1 locus     
   wt/wt 155 (59%) 165 (59%) 327 (79%) 325 (78%)
   wt/M1 93 (35%) 102 (36%) 78 (19%) 83 (20%)
   M1/M1 17 (6%) 13 (5%) 8 (2%) 7 (2%)
   Missing 6 5 4 2
   Chi-square test, P*   0.65   0.89
M2 locus     
   wt/wt 259 (96%) 274 (96%) 385 (92%) 378 (90%)
   wt/M2 12 (4%) 11 (4%) 29 (7%) 37 (9%)
   M2/M2 0 0 3 (1%) 2 (1%)
   Missing 0 0 0 0
   Fisher's exact test, P*   0.83   0.61
M3 locus     
   wt/wt 218 (82%) 227 (81%) 412 (99.8%) 413 (99.6%)
   wt/M3 47 (18%) 47 (17%) 1 (0.2%) 1 (0.2%)
   M3/M3 0 6 (2%) 0 1 (0.2%)
   Missing 6 5 4 2
   Fisher's exact test, P*   0.06   0.99
M4 locus     
   wt/wt 267 (98.5%) 278 (97.5%) 378 (90.7%) 377 (90%)
   wt/M4 3 (1.1%) 7 (2.5%) 38 (9.1%) 40 (10%)
   M4/M4 1 (0.4%) 0 1 (0.2%) 0
   Missing 0 0 0 0
   Fisher's exact test, P*   0.28   0.91
  1. Data presented as n (%). wt, wild type. * Comparing cases and controls.