Table 7 Association of HIF-1α with cell cycle-related proteins in only ductal carcinoma, subdivided into estrogen receptor-positive (n = 46) and estrogen receptor-negative (n = 83) breast cancers
Protein | Cutoff value | Estrogen receptor-positive | Estrogen receptor-negative | ||||
|---|---|---|---|---|---|---|---|
HIF-1 α | P(χ2) | HIF-1 α | P(χ2) | ||||
<5% | ≥5% | <5% | ≥5% | ||||
Ki-67 | ≤10% | 20 | 5 | 0.730 | 24 | 6 | 0.002 |
>10% | 15 | 6 | 24 | 29 | |||
Cyclin A | ≤10% | 24 | 7 | 0.717 | 28 | 9 | 0.003 |
>10% | 10 | 4 | 20 | 26 | |||
Cyclin D1 | ≤10% | 22 | 7 | 0.100 | 45 | 32 | 0.693 |
>10% | 13 | 4 | 3 | 3 | |||
p21 | ≤10% | 29 | 5 | 0.022 | 46 | 31 | 0.235 |
>10% | 6 | 6 | 2 | 4 | |||
p53 | ≤25% | 29 | 7 | 0.175 | 39 | 18 | 0.008 |
>25% | 6 | 4 | 9 | 17 | |||
Bcl-2 | Negative | 0 | 0 | 0.477 | 4 | 5 | 0.141 |
Moderate | 11 | 5 | 18 | 18 | |||
Strong | 24 | 6 | 26 | 11 | |||
VEGF | Weak | 8 | 2 | 1.00 | 18 | 3 | 0.003 |
Strong | 27 | 9 | 30 | 32 | |||
HER-2/neu | Negative | 33 | 8 | 0.080 | 43 | 23 | 0.008 |
Positive | 2 | 3 | 5 | 12 | |||