Skip to main content

Table 7 Association of HIF-1α with cell cycle-related proteins in only ductal carcinoma, subdivided into estrogen receptor-positive (n = 46) and estrogen receptor-negative (n = 83) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value Estrogen receptor-positive   Estrogen receptor-negative  
   HIF-1 α P2) HIF-1 α P2)
   <5% ≥5%   <5% ≥5%  
Ki-67 ≤10% 20 5 0.730 24 6 0.002
  >10% 15 6   24 29  
Cyclin A ≤10% 24 7 0.717 28 9 0.003
  >10% 10 4   20 26  
Cyclin D1 ≤10% 22 7 0.100 45 32 0.693
  >10% 13 4   3 3  
p21 ≤10% 29 5 0.022 46 31 0.235
  >10% 6 6   2 4  
p53 ≤25% 29 7 0.175 39 18 0.008
  >25% 6 4   9 17  
Bcl-2 Negative 0 0 0.477 4 5 0.141
  Moderate 11 5   18 18  
  Strong 24 6   26 11  
VEGF Weak 8 2 1.00 18 3 0.003
  Strong 27 9   30 32  
HER-2/neu Negative 33 8 0.080 43 23 0.008
  Positive 2 3   5 12  
  1. aFisher Exact Test when appropriate. HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor.