|
Protein
|
Cutoff value
|
Estrogen receptor-positive
| |
Estrogen receptor-negative
| |
|---|
| | |
HIF-1 α
|
P(χ2)
|
HIF-1 α
|
P(χ2)
|
|---|
| | |
<5%
|
≥5%
| |
<5%
|
≥5%
| |
|---|
|
Ki-67
|
≤10%
|
20
|
5
|
0.730
|
24
|
6
|
0.002
|
| |
>10%
|
15
|
6
| |
24
|
29
| |
|
Cyclin A
|
≤10%
|
24
|
7
|
0.717
|
28
|
9
|
0.003
|
| |
>10%
|
10
|
4
| |
20
|
26
| |
|
Cyclin D1
|
≤10%
|
22
|
7
|
0.100
|
45
|
32
|
0.693
|
| |
>10%
|
13
|
4
| |
3
|
3
| |
|
p21
|
≤10%
|
29
|
5
|
0.022
|
46
|
31
|
0.235
|
| |
>10%
|
6
|
6
| |
2
|
4
| |
|
p53
|
≤25%
|
29
|
7
|
0.175
|
39
|
18
|
0.008
|
| |
>25%
|
6
|
4
| |
9
|
17
| |
|
Bcl-2
|
Negative
|
0
|
0
|
0.477
|
4
|
5
|
0.141
|
| |
Moderate
|
11
|
5
| |
18
|
18
| |
| |
Strong
|
24
|
6
| |
26
|
11
| |
|
VEGF
|
Weak
|
8
|
2
|
1.00
|
18
|
3
|
0.003
|
| |
Strong
|
27
|
9
| |
30
|
32
| |
|
HER-2/neu
|
Negative
|
33
|
8
|
0.080
|
43
|
23
|
0.008
|
| |
Positive
|
2
|
3
| |
5
|
12
| |
-
aFisher Exact Test when appropriate. HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor.
