Table 6 Association of HIF-1α expression with cell cycle-related proteins in all ductal type (129 of 150) invasive human breast cancers
Protein | Cutoff value | Concentration of HIF-1α | P(χ2) | |
|---|---|---|---|---|
<5% | ≥5% | |||
Ki-67 | ≤10% | 44 | 11 | 0.001 |
>10% | 39 | 35 | ||
Cyclin A | ≤10% | 52 | 16 | 0.002 |
>10% | 30 | 30 | ||
Cyclin D1 | ≤10% | 67 | 39 | 0.564 |
>10% | 16 | 7 | ||
p21 | ≤10% | 75 | 36 | 0.057 |
>10% | 8 | 10 | ||
p53 | ≤25% | 68 | 25 | 0.001 |
>25% | 15 | 21 | ||
Bcl-2 | Negative | 4 | 5 | 0.042 |
Moderate | 29 | 23 | ||
Strong | 50 | 17 | ||