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Table 6 Association of HIF-1α expression with cell cycle-related proteins in all ductal type (129 of 150) invasive human breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value Concentration of HIF-1α P2)
   <5% ≥5%  
Ki-67 ≤10% 44 11 0.001
  >10% 39 35  
Cyclin A ≤10% 52 16 0.002
  >10% 30 30  
Cyclin D1 ≤10% 67 39 0.564
  >10% 16 7  
p21 ≤10% 75 36 0.057
  >10% 8 10  
p53 ≤25% 68 25 0.001
  >25% 15 21  
Bcl-2 Negative 4 5 0.042
  Moderate 29 23  
  Strong 50 17  
  1. HIF, hypoxia-inducible factor.