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Table 5 Association of HIF-1α with cell cycle-related proteins in lymph node-negative (n = 81) and lymph node-positive (n = 69) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein

Cutoff value

Lymph node-negative

 

Lymph node-positive

 
  

HIF-1 α

P2)

HIF-1 α

P2)

  

<5%

≥5%

 

<5%

≥5%

 

Ki-67

≤10%

36

9

<0.001

22

4

0.035

 

>10%

15

21

 

26

17

 

Cyclin A

≤10%

40

10

<0.001

27

9

0.305

 

>10%

10

20

 

21

12

 

Cyclin D1

≤10%

40

25

0.593

40

19

0.438

 

>10%

11

5

 

8

2

 

p21

≤10%

47

23

0.049

42

18

0.839

 

>10%

4

7

 

6

3

 

p53

≤25%

47

21

0.009

42

14

0.042

 

>25%

4

9

 

6

7

 

Bcl-2

Negative

0

3

0.008

4

2

0.459

 

Moderate

17

15

 

18

11

 
 

Strong

34

11

 

26

8

 
  1. HIF, hypoxia-inducible factor.