Protein | Cutoff value | Lymph node-negative | Lymph node-positive | ||||
---|---|---|---|---|---|---|---|
HIF-1 α | P(χ2) | HIF-1 α | P(χ2) | ||||
<5% | ≥5% | <5% | ≥5% | ||||
Ki-67 | ≤10% | 36 | 9 | <0.001 | 22 | 4 | 0.035 |
>10% | 15 | 21 | 26 | 17 | |||
Cyclin A | ≤10% | 40 | 10 | <0.001 | 27 | 9 | 0.305 |
>10% | 10 | 20 | 21 | 12 | |||
Cyclin D1 | ≤10% | 40 | 25 | 0.593 | 40 | 19 | 0.438 |
>10% | 11 | 5 | 8 | 2 | |||
p21 | ≤10% | 47 | 23 | 0.049 | 42 | 18 | 0.839 |
>10% | 4 | 7 | 6 | 3 | |||
p53 | ≤25% | 47 | 21 | 0.009 | 42 | 14 | 0.042 |
>25% | 4 | 9 | 6 | 7 | |||
Bcl-2 | Negative | 0 | 3 | 0.008 | 4 | 2 | 0.459 |
Moderate | 17 | 15 | 18 | 11 | |||
Strong | 34 | 11 | 26 | 8 |