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Table 5 Association of HIF-1α with cell cycle-related proteins in lymph node-negative (n = 81) and lymph node-positive (n = 69) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value Lymph node-negative   Lymph node-positive  
   HIF-1 α P2) HIF-1 α P2)
   <5% ≥5%   <5% ≥5%  
Ki-67 ≤10% 36 9 <0.001 22 4 0.035
  >10% 15 21   26 17  
Cyclin A ≤10% 40 10 <0.001 27 9 0.305
  >10% 10 20   21 12  
Cyclin D1 ≤10% 40 25 0.593 40 19 0.438
  >10% 11 5   8 2  
p21 ≤10% 47 23 0.049 42 18 0.839
  >10% 4 7   6 3  
p53 ≤25% 47 21 0.009 42 14 0.042
  >25% 4 9   6 7  
Bcl-2 Negative 0 3 0.008 4 2 0.459
  Moderate 17 15   18 11  
  Strong 34 11   26 8  
  1. HIF, hypoxia-inducible factor.