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Table 4 Association of HIF-1α with cell cycle-related proteins in WT-p53 (n = 124) and M-p53 (n = 26) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein

Cutoff value

'Wild type' p53

 

'Mutated' p53

 
  

HIF-1 α

P2)

HIF-1 α

P2)

  

<5%

≥5%

 

<5%

≥5%

 

Ki-67

≤10%

55

12

0.006

3

1

0.264

 

>10%

34

23

 

7

15

 

Cyclin A

≤10%

62

15

0.004

5

4

0.192

 

>10%

26

20

 

5

12

 

Cyclin D1

≤10%

71

31

0.248

9

13

1.00

 

>10%

18

4

 

1

3

 

p21

≤10%

80

28

0.139

9

13

1.00

 

>10%

9

7

 

1

3

 

Bcl-2

Negative

3

3

0.273

1

2

0.132

 

Moderate

31

15

 

4

11

 
 

Strong

55

17

 

5

2

 

VEGF

Weak

28

5

0.051

1

1

1.00

 

Strong

61

30

 

9

15

 

HER-2/neu

Negative

82

27

0.021

9

8

0.037

 

Positive

7

8

 

1

8

 
  1. aFisher Exact Test when appropriate. HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor; WT-p53, probably wild type p53; M-p53, probably mutated p53.