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Table 4 Association of HIF-1α with cell cycle-related proteins in WT-p53 (n = 124) and M-p53 (n = 26) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value 'Wild type' p53   'Mutated' p53  
   HIF-1 α P2) HIF-1 α P2)
   <5% ≥5%   <5% ≥5%  
Ki-67 ≤10% 55 12 0.006 3 1 0.264
  >10% 34 23   7 15  
Cyclin A ≤10% 62 15 0.004 5 4 0.192
  >10% 26 20   5 12  
Cyclin D1 ≤10% 71 31 0.248 9 13 1.00
  >10% 18 4   1 3  
p21 ≤10% 80 28 0.139 9 13 1.00
  >10% 9 7   1 3  
Bcl-2 Negative 3 3 0.273 1 2 0.132
  Moderate 31 15   4 11  
  Strong 55 17   5 2  
VEGF Weak 28 5 0.051 1 1 1.00
  Strong 61 30   9 15  
HER-2/neu Negative 82 27 0.021 9 8 0.037
  Positive 7 8   1 8  
  1. aFisher Exact Test when appropriate. HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor; WT-p53, probably wild type p53; M-p53, probably mutated p53.