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Table 3 Association of HIF-1α with cell cycle-related proteins in estrogen receptor-positive (n = 52) and estrogen receptor-negative (n = 98) breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value ER-positive   ER-negative  
   HIF-1 α P2) HIF-1 α P2)
   <5% ≥5%   <5% ≥5%  
Ki-67 ≤10% 24 7 0.624 34 6 <0.001
  >10% 15 7   26 32  
Cyclin A ≤10% 28 9 0.756 39 10 <0.001
  >10% 10 4   21 28  
Cyclin D1 ≤10% 25 9 0.736 55 35 0.938
  >10% 14 4   5 3  
p21 ≤10% 33 7 0.023 56 34 0.497
  >10% 6 6   4 4  
p53 ≤25% 36 11 0.415 53 24 0.003
  >25% 3 2   7 14  
Bcl-2 Negative 0 0 0.609 4 5 0.048
  Moderate 12 5   23 21  
  Strong 27 8   33 11  
VEGF Weak 8 2 0.685 21 4 0.007
  Strong 31 11   39 34  
HER-2/neu Negative 36 9 0.035 55 26 0.003
  Positive 3 4   5 12  
  1. ER, estrogen receptor; HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor.