|
Protein
|
Cutoff value
|
ER-positive
| |
ER-negative
| |
|---|
| | |
HIF-1 α
|
P(χ2)
|
HIF-1 α
|
P(χ2)
|
|---|
| | |
<5%
|
≥5%
| |
<5%
|
≥5%
| |
|---|
|
Ki-67
|
≤10%
|
24
|
7
|
0.624
|
34
|
6
|
<0.001
|
| |
>10%
|
15
|
7
| |
26
|
32
| |
|
Cyclin A
|
≤10%
|
28
|
9
|
0.756
|
39
|
10
|
<0.001
|
| |
>10%
|
10
|
4
| |
21
|
28
| |
|
Cyclin D1
|
≤10%
|
25
|
9
|
0.736
|
55
|
35
|
0.938
|
| |
>10%
|
14
|
4
| |
5
|
3
| |
|
p21
|
≤10%
|
33
|
7
|
0.023
|
56
|
34
|
0.497
|
| |
>10%
|
6
|
6
| |
4
|
4
| |
|
p53
|
≤25%
|
36
|
11
|
0.415
|
53
|
24
|
0.003
|
| |
>25%
|
3
|
2
| |
7
|
14
| |
|
Bcl-2
|
Negative
|
0
|
0
|
0.609
|
4
|
5
|
0.048
|
| |
Moderate
|
12
|
5
| |
23
|
21
| |
| |
Strong
|
27
|
8
| |
33
|
11
| |
|
VEGF
|
Weak
|
8
|
2
|
0.685
|
21
|
4
|
0.007
|
| |
Strong
|
31
|
11
| |
39
|
34
| |
|
HER-2/neu
|
Negative
|
36
|
9
|
0.035
|
55
|
26
|
0.003
|
| |
Positive
|
3
|
4
| |
5
|
12
| |
- ER, estrogen receptor; HIF, hypoxia-inducible factor; VEGF, vascular endothelial growth factor.
