Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Table 2 Association of HIF-1α expression with cell cycle-related proteins in 150 invasive human breast cancers

Protein	Cutoff value	Concentration of HIF-1α		P(χ²)
		<5%	≥5%
Ki-67	≤10%	58	13	<0.001
	>10%	41	38
Cyclin A	≤10%	67	19	<0.001
	>10%	31	32
Cyclin D₁	≤10%	80	44	0.402
	>10%	19	7
p21	≤10%	89	41	0.105
	>10%	10	10
p53	≤25%	89	35	<0.001
	>25%	10	16
Bcl-2	Negative	4	5	0.025
	Moderate	35	26
	Strong	60	19

ISSN: 1465-542X