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Table 2 Association of HIF-1α expression with cell cycle-related proteins in 150 invasive human breast cancers

From: Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

Protein Cutoff value Concentration of HIF-1α P2)
   <5% ≥5%  
Ki-67 ≤10% 58 13 <0.001
  >10% 41 38  
Cyclin A ≤10% 67 19 <0.001
  >10% 31 32  
Cyclin D1 ≤10% 80 44 0.402
  >10% 19 7  
p21 ≤10% 89 41 0.105
  >10% 10 10  
p53 ≤25% 89 35 <0.001
  >25% 10 16  
Bcl-2 Negative 4 5 0.025
  Moderate 35 26  
  Strong 60 19  
  1. HIF, hypoxia-inducible factor.