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Table 1 Characteristics of index cases and families

From: Frequency of the ATM IVS10-6T→G variant in Australian multiple-case breast cancer families

Characteristic GHSV, RMH and WHa SAFCS Total
Total number of families 294 201 495
Average number of female breast cancer cases per family 3.4 3.2  
Average number of ovarian cancer cases per family 0.42 0.25  
Average age of index case breast cancer diagnosis (years) 45.1 48.2  
High risk 270 (91.8%) 179 (89.0%) 449 (90.7%)
   With breast and ovarian cancer cases 77 (26.2%)   
   With breast cancer cases and high-risk featuresb 142 (48.3%)   
   With breast cancer cases and no high-risk featuresc 51 (17.3%)   
Moderate risk 22 (7.5%) 15 (7.5%) 37 (7.5%)
Risk status not known 2 (0.7%) 7 (3.5%) 9 (1.8%)
  1. aWH cases (n = 161) included 31 known BRCA1 carriers. bAt least two breast cancers, one of which has the following features: age onset 40 years or less, bilateral (or multifocal) disease, male breast cancer, Ashkenazi ancestry. cThree or more breast cancers with no high-risk features.