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Table 1 Characteristics of index cases and families

From: Frequency of the ATM IVS10-6T→G variant in Australian multiple-case breast cancer families

Characteristic

GHSV, RMH and WHa

SAFCS

Total

Total number of families

294

201

495

Average number of female breast cancer cases per family

3.4

3.2

 

Average number of ovarian cancer cases per family

0.42

0.25

 

Average age of index case breast cancer diagnosis (years)

45.1

48.2

 

High risk

270 (91.8%)

179 (89.0%)

449 (90.7%)

   With breast and ovarian cancer cases

77 (26.2%)

  

   With breast cancer cases and high-risk featuresb

142 (48.3%)

  

   With breast cancer cases and no high-risk featuresc

51 (17.3%)

  

Moderate risk

22 (7.5%)

15 (7.5%)

37 (7.5%)

Risk status not known

2 (0.7%)

7 (3.5%)

9 (1.8%)

  1. aWH cases (n = 161) included 31 known BRCA1 carriers. bAt least two breast cancers, one of which has the following features: age onset 40 years or less, bilateral (or multifocal) disease, male breast cancer, Ashkenazi ancestry. cThree or more breast cancers with no high-risk features.