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Table 3 Genotype frequencies of tumour necrosis factor (TNF) polymorphisms in relation to pathological indices of breast cancer severity

From: Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity

Pathological feature Number of patients (%) P value
  GG GA AA  
TNF -238 polymorphism     
Nodal status     
   Negative 387 (88.8) 46 (10.6) 3 (0.7)  
   Positive 171 (85.5) 29 (14.5) 0 (0) 0.20a
Grade     
   Grade 1/2 363 (88.1) 47 (11.4) 2 (0.5)  
   Grade 3 189 (87.1) 27 (12.4) 1 (0.5) 0.87a
Vascular invasion     
   Negative 417 (88.3) 53 (11.2) 2 (0.4)  
   Positive 105 (89.0) 13 (11.0) 0 (0) 1.0a
TNF -308 polymorphism     
Nodal status     
   Negative 299 (68.9) 123 (28.3) 12 (2.8)  
   Positive 129 (64.8) 62 (31.2) 8 (4.0) 0.50b
Grade     
   Grade 1/2 286 (69.6) 112 (27.3) 13 (3.2)  
   Grade 3 140 (65.1) 68 (31.6) 7 (3.3) 0.50b
Vascular invasion     
   Negative 326 (69.2) 132 (28.0) 13 (2.8)  
   Positive 70 (60.3) 38 (32.8) 8 (6.9) 0.044b
  1. a Fisher's exact test. b Chi-square test.
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Breast Cancer Research

ISSN: 1465-542X

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